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Generated: October 22, 2017

DrugPatentWatch Database Preview

Details for Patent: 5,002,776

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Summary for Patent: 5,002,776

Title: Controlled absorption diltiazem formulations
Abstract:A controlled absorption diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid, and a multi-layer membrane surrounding the core and containing a major proportion of a pharmaceutically acceptable film-forming water insoluble synthetic polymer and optionally a minor proportion of a pharmaceutically acceptable film-forming, water soluble synthetic polymer. The number of layers in the membrane and the ratio of the water soluble to water insoluble polymer, when said water soluble polymer is present, being effective to permit release of diltiazem from the pellet at a rate allowing controlled absorption thereof over not less than a twelve hour period following oral administration. The pellet has a dissolution rate in vitro which when measured in a dissolution apparatus (paddle) according to U.S. Pharmacopoeia XXI in 0.05 M KCl at pH 7.0 results in not more than 35% of the total diltiazem being released after 2 hours of measurement. Not more than 60% of the total diltiazem is released after four hours of measurement and 100% of the diltiazem is released no earlier than after 8 hours of measurement in said apparatus.
Inventor(s): Geoghegan; Edward J. (Athlone, IE), Mulligan; Seamus (Athlone, IE), Panoz; Donald E. (Tuckers Town, BM)
Assignee: Elan Corporation, PLC (Athlone, IE)
Application Number:07/273,192
Patent Claim Types:
see list of patent claims
Formulation; Compound; Dosage form; Device; Process;

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Foreign Priority and PCT Information for Patent: 5,002,776

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Ireland3158/87Nov 20, 1987
Ireland822/88Mar 22, 1988

International Patent Family for Patent: 5,002,776

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Spain2194832► Subscribe
Ireland833057► Subscribe
Switzerland662507► Subscribe
Germany3485023► Subscribe
Germany3856555► Subscribe
Denmark575688► Subscribe
Denmark175591► Subscribe
European Patent Office0149920► Subscribe
European Patent Office0320097► Subscribe
European Patent Office0856313► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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