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Serving leading biopharmaceutical companies globally:

Fish and Richardson
Argus Health
Express Scripts
Johnson and Johnson

Generated: December 11, 2017

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Details for Patent: 4,951,675

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Summary for Patent: 4,951,675

Title: Biodegradable superparamagnetic metal oxides as contrast agents for MR imaging
Abstract:This invention relates to materials exhibiting certain magnetic and biological properties which make them uniquely suitable for use as magnetic resonance imaging (MRI) agents to enhance MR images of animal organs and tissues. More particularly, the invention relates to the in vivo use of biologically degradable and metabolizable superparamagnetic metal oxides as MR contrast agents. Depending on their preparation, these metal oxides are in the form of superparamagnetic particle dispersoids or superparamagnetic fluids where the suspending medium is a physiologically-acceptable carrier, and may be uncoated or surrounded by a polymeric coating to which biological molecules can be attached. These materials are administered to animals, including humans, by a variety of routes and the metal oxides therein collect in specific target organs to be imaged; in the case of coated particles, the biological molecules can be chosen to target specific organs or tissues. The biodistribution of the metal oxides in target organs or tissues results in a more detailed image of such organs or tissues because the metal oxides, due to their superparamagnetic properties, exert profound effects on the hydrogen nuclei responsible for the MR image. In addition, the dispersoids and fluids are quite stable and, in the case of the fluids, can even be subjected to autoclaving without impairing their utility. Furthermore, the materials are biodegradable and, in the case of iron oxide compounds, can eventually be incorporated into the subject's hemoglobin, making them useful in treating anemia. Thus, the materials are well-suited for in vivo use.
Inventor(s): Groman; Ernest V. (Brookline, MA), Josephson; Lee (Arlington, MA), Lewis; Jerome M. (Newton, MA)
Assignee: Advanced Magnetics, Incorporated (Cambridge, MA)
Application Number:07/244,432
Patent Claim Types:
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Use; Composition;

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International Patent Family for Patent: 4,951,675

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria135920► Subscribe
Austria139431► Subscribe
Austria142891► Subscribe
Austria143604► Subscribe
Austria143814► Subscribe
Austria151991► Subscribe
Australia2545292► Subscribe
Australia2700195► Subscribe
Canada1301063► Subscribe
Canada2075491► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

Chinese Patent Office
Fish and Richardson
Boehringer Ingelheim
Queensland Health
Federal Trade Commission

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