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Serving leading biopharmaceutical companies globally:

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Generated: January 21, 2018

DrugPatentWatch Database Preview

Details for Patent: 4,933,456

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Summary for Patent: 4,933,456
Title: Dipyridoxyl phosphate NMRI contrast agents
Abstract:N,N'-bis-(pyridoxal-5-phosphate)-alkylenediamine-N,N'-diacetic acids, N,N'-bis-(pyridoxal-5-phosphate)-1,2-cycloalkylenediamine-N,N'-diacetic acids, and N,N'-bis-(pyridoxal-5-phosphate)-1,2-arylenediamine-N,N'-diacetic acids, the corresponding monophosphate compounds and monoacetic acid compounds, and their salts and esters form stable, highly soluble chelates with paramagnetic metal ions, and are highly effective NMRI contrast agents. Preferred contrast agents are paramagnetic ion chelates of N,N'-bis-(pyridoxal-5-phosphate)ethylene-diamine-N,N'-diacetic acid, N,N'-bis-(pyridoxal-5-phosphate)trans-1,2-cyclohexylenediamine-N,N'-diacet ic acid, N,N'-bis-(pyridoxal-5-phosphate)trans-1,2-arylenediamine-N,N'-diacetic acid, and the soluble calcium salts thereof. Novel intermediates for forming these compounds are N,N'-bis(pyridoxal-5-phosphate)alkylenediimines, N,N'-bis(pyridoxal-5-phosphate)alkylenediamines, N,N'-bis(pyridoxal-5-phosphate)-1,2-cycloalkylenediimines, N,N'-bis(pyridoxal-5-phosphate)-1,2-cycloalkylenediamines, N,N'-bis(pyridoxal-5-phosphate(-1,2-arylenediamines, and the corresponding monophosphate compounds.
Inventor(s): Rocklage; Scott M. (Saratoga, CA), Quay; Steven C. (Los Altos Hills, CA)
Assignee: Salutar, Inc. (Sunnyvale, CA)
Application Number:07/047,614
Patent Claim Types:
see list of patent claims
Compound;

Drugs Protected by US Patent 4,933,456

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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International Patents Family Members for US Patent 4,933,456

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Argentina 246956 ➤ Subscribe
Austria 118010 ➤ Subscribe
Australia 1568088 ➤ Subscribe
Australia 613363 ➤ Subscribe
Brazil 1100623 ➤ Subscribe
Canada 1322003 ➤ Subscribe
Germany 19775088 ➤ Subscribe
Germany 3852906 ➤ Subscribe
Denmark 173849 ➤ Subscribe
Denmark 251688 ➤ Subscribe
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving leading biopharmaceutical companies globally:

Novartis
Queensland Health
Chinese Patent Office
Federal Trade Commission
Daiichi Sankyo
Baxter
Teva
Cipla
Mallinckrodt

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