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Chubb
Teva
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Generated: April 25, 2018

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Details for Patent: 4,933,456

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Summary for Patent: 4,933,456
Title: Dipyridoxyl phosphate NMRI contrast agents
Abstract:N,N'-bis-(pyridoxal-5-phosphate)-alkylenediamine-N,N'-diacetic acids, N,N'-bis-(pyridoxal-5-phosphate)-1,2-cycloalkylenediamine-N,N'-diacetic acids, and N,N'-bis-(pyridoxal-5-phosphate)-1,2-arylenediamine-N,N'-diacetic acids, the corresponding monophosphate compounds and monoacetic acid compounds, and their salts and esters form stable, highly soluble chelates with paramagnetic metal ions, and are highly effective NMRI contrast agents. Preferred contrast agents are paramagnetic ion chelates of N,N'-bis-(pyridoxal-5-phosphate)ethylene-diamine-N,N'-diacetic acid, N,N'-bis-(pyridoxal-5-phosphate)trans-1,2-cyclohexylenediamine-N,N'-diacet ic acid, N,N'-bis-(pyridoxal-5-phosphate)trans-1,2-arylenediamine-N,N'-diacetic acid, and the soluble calcium salts thereof. Novel intermediates for forming these compounds are N,N'-bis(pyridoxal-5-phosphate)alkylenediimines, N,N'-bis(pyridoxal-5-phosphate)alkylenediamines, N,N'-bis(pyridoxal-5-phosphate)-1,2-cycloalkylenediimines, N,N'-bis(pyridoxal-5-phosphate)-1,2-cycloalkylenediamines, N,N'-bis(pyridoxal-5-phosphate(-1,2-arylenediamines, and the corresponding monophosphate compounds.
Inventor(s): Rocklage; Scott M. (Saratoga, CA), Quay; Steven C. (Los Altos Hills, CA)
Assignee: Salutar, Inc. (Sunnyvale, CA)
Application Number:07/047,614
Patent Claim Types:
see list of patent claims
Compound;

Drugs Protected by US Patent 4,933,456

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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International Family Members for US Patent 4,933,456

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Germany 19775088 ➤ Try a Free Trial
Denmark 251688 ➤ Try a Free Trial
Denmark 173849 ➤ Try a Free Trial
European Patent Office 0290047 ➤ Try a Free Trial C00290047/01 Switzerland ➤ Try a Free Trial
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Serving hundreds of leading biopharmaceutical companies globally:

Healthtrust
AstraZeneca
Accenture
Fish and Richardson
Teva
Argus Health
Cantor Fitzgerald
McKesson
Covington

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