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Serving hundreds of leading biopharmaceutical companies globally:

Fuji
Express Scripts
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Argus Health
Colorcon
QuintilesIMS
Chinese Patent Office
McKinsey
Cantor Fitzgerald

Generated: June 22, 2018

DrugPatentWatch Database Preview

Details for Patent: 4,927,814

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Summary for Patent: 4,927,814
Title: Diphosphonate derivatives, pharmaceutical compositions and methods of use
Abstract:The present invention provides disphosphonates of the general formula: ##STR1## wherein R.sub.1 is a straight-chain or branched, saturated or unsaturated aliphatic hydrocarbon radical of 1-9 carbon atoms which is optionally substituted by phenyl or cyclohexyl, R.sub.2 is cyclohexyl or cyclohexylmethyl, benzyl or a straight-chained or branched, saturated or unsaturated aliphatic hydrocarbon of 4 to 18 carbon atoms which is optionally substituted by phenyl or oxygen wherein the oxygen can be esterified or etherified, R.sub.3 is hydrogen or a straight-chain or branched alkyl of 1-4 carbon atoms, X is a straight-chain or branched alkylene chain of 1-6 carbon atoms and Y is hydrogen, hydroxyl or an amino group optionally substituted by alkyl radicals of 1-6 carbon atoms; as well as the pharmacologically acceptable salts thereof. The present invention also provides processes for the preparation of these diphosphonic acid derivatives and pharmaceutical compositions containing them for the prophyllaxis treatment of diseases or disturbances of calcium metabolism such as osteoporsis, Pagets disease, Bechterew's disease, bone metastases, urolithiasis, heterotropic ossifications, rheumatoid arthritis, osteoarthritis and degenerative arthrosis.
Inventor(s): Gall; Rudi (Hirschberg, DE), Bosies; Elmar (Weinheim, DE)
Assignee: Boehringer Mannheim GmbH (Mannheim, DE)
Application Number:07/071,471
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 4,927,814
Patent Claim Types:
see list of patent claims
Compound; Use; Composition;

Drugs Protected by US Patent 4,927,814

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Foreign Priority and PCT Information for Patent: 4,927,814

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Germany3623397Jul 11, 1986

International Family Members for US Patent 4,927,814

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria 54000 ➤ Try a Free Trial
Austria 80633 ➤ Try a Free Trial
Australia 598279 ➤ Try a Free Trial
Australia 598569 ➤ Try a Free Trial
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Express Scripts
Fuji
Moodys
Covington
Healthtrust
UBS
Johnson and Johnson
Harvard Business School
Argus Health

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