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Serving hundreds of leading biopharmaceutical companies globally:

Moodys
Boehringer Ingelheim
Covington
US Department of Justice
Mallinckrodt
McKesson
Healthtrust
Julphar
Cantor Fitzgerald

Generated: April 23, 2018

DrugPatentWatch Database Preview

Details for Patent: 4,927,814

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Summary for Patent: 4,927,814
Title: Diphosphonate derivatives, pharmaceutical compositions and methods of use
Abstract:The present invention provides disphosphonates of the general formula: ##STR1## wherein R.sub.1 is a straight-chain or branched, saturated or unsaturated aliphatic hydrocarbon radical of 1-9 carbon atoms which is optionally substituted by phenyl or cyclohexyl, R.sub.2 is cyclohexyl or cyclohexylmethyl, benzyl or a straight-chained or branched, saturated or unsaturated aliphatic hydrocarbon of 4 to 18 carbon atoms which is optionally substituted by phenyl or oxygen wherein the oxygen can be esterified or etherified, R.sub.3 is hydrogen or a straight-chain or branched alkyl of 1-4 carbon atoms, X is a straight-chain or branched alkylene chain of 1-6 carbon atoms and Y is hydrogen, hydroxyl or an amino group optionally substituted by alkyl radicals of 1-6 carbon atoms; as well as the pharmacologically acceptable salts thereof. The present invention also provides processes for the preparation of these diphosphonic acid derivatives and pharmaceutical compositions containing them for the prophyllaxis treatment of diseases or disturbances of calcium metabolism such as osteoporsis, Pagets disease, Bechterew's disease, bone metastases, urolithiasis, heterotropic ossifications, rheumatoid arthritis, osteoarthritis and degenerative arthrosis.
Inventor(s): Gall; Rudi (Hirschberg, DE), Bosies; Elmar (Weinheim, DE)
Assignee: Boehringer Mannheim GmbH (Mannheim, DE)
Application Number:07/071,471
Patent Claim Types:
see list of patent claims
Compound; Use; Composition;

Drugs Protected by US Patent 4,927,814

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Foreign Priority and PCT Information for Patent: 4,927,814

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Germany3623397Jul 11, 1986

International Patents Family Members for US Patent 4,927,814

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Finland 873058 ➤ Try a Free Trial
Finland 85026 ➤ Try a Free Trial
Finland 881134 ➤ Try a Free Trial
Spain 2043622 ➤ Try a Free Trial
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Harvard Business School
Queensland Health
Healthtrust
Covington
McKinsey
Cantor Fitzgerald
Federal Trade Commission
Medtronic
Baxter

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