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Generated: December 17, 2017

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Details for Patent: 4,886,812

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Summary for Patent: 4,886,812

Title: Tetrahydro-benzthiazoles, the preparation thereof and their use as intermediate products or as pharmaceuticals
Abstract:This invention relates to new tetrahydrobenzthiazoles of general formula ##STR1## wherein R.sub.1 represents a hydrogen atom, an alkyl group, an alkenyl or alkynyl group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the above mentioned phenyl nucleic may each be substituted by 1 or 2 halogen atoms, R.sub.2 represents a hydrogen atom or an alkyl group, R.sub.3 represents a hydrogen atom, an alkyl group a cycloalkyl group, an alkenyl or alkynyl group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the phenyl nucleus may be substituted by fluorine, chlorine or bromine atoms, R.sub.4 represents a hydrogen atom, an alkyl group, an alkyl or alkenyl group, or R.sub.3 and R.sub.4 together with the nitrogen atom between them represent a pyrrolidino, piperidino, hexamethyleneimino or morpholino group, the enantiomers and the acid addition salts thereof. The compounds of general formula I above in which one of the groups R.sub.1 or R.sub.3 or both groups R.sub.1 and R.sub.3 represent an acyl group are valuable intermediate products for preparing the other compounds of general formula I which have valuable pharmacological properties. The new compounds may be prepared using methods known per se.
Inventor(s): Griss, deceased; Gerhart (late of Biberach, DE), Schneider; Claus (Ingelheim am Rhein, DE), Hurnaus; Rudolf (Biberach, DE), Kobinger; Walter (Vienna, AT), Pichler; Ludwig (Vienna, AT), Bauer; Rudolf (Wiesbaden, DE), Mierau; Joachim (Mainz, DE), Hinzen; Dieter (Zornheim, DE), Schingnitz; Gunter (Bad Kreuznach, DE)
Assignee: Dr. Karl Thomae GmbH (Biberach an der Riss, DE)
Application Number:07/256,671
Patent Claim Types:
see list of patent claims
Compound; Use; Composition;

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Foreign Priority and PCT Information for Patent: 4,886,812

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Germany34470751Dec 22, 1984
Germany3508947Mar 13, 1985

International Patent Family for Patent: 4,886,812

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Spain8707515► Subscribe
Spain556875► Subscribe
Spain8707514► Subscribe
Spain556874► Subscribe
Spain8707513► Subscribe
Spain556873► Subscribe
Spain8702787► Subscribe
Spain550235► Subscribe
European Patent Office0186087► SubscribeSPC/GB98/017United Kingdom► Subscribe
European Patent Office0186087► SubscribeC980002Netherlands► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

Daiichi Sankyo
Argus Health

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