Generated: December 15, 2017
DrugPatentWatch Database Preview
Details for Patent: 4,880,631
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Summary for Patent: 4,880,631
|Title:|| Controlled porosity osmotic pump|
|Abstract:||The instant invention is directed to an osmotic pump, for the controlled release of diltiazem L-malate to an environment of use, said pump comprising: (A) a core which comprises a therapeutically effective amount of diltiazem L-malate and an effective buffering amount of sodium bitartrate surrounded by (B) a rate controlling water insoluble wall, having a fluid permeability of 6.96.times.10.sup.-18 to 6.96.times.10.sup.-14 cm.sup.3 sec/g and a reflection coefficient of less than 0.5, prepared from: (i) a polymer permeable to water but impermeable to solute and (ii) 0.1 to 60% by weight, based on the total weight of (i) and (ii), of at least one pH insensitive pore forming additive dispersed throughout said wall.|
|Inventor(s):|| Haslam; John L. (Lawrence, KS), Rork; Gerald S. (Lawrence, KS) |
|Assignee:|| Merck & Co., Inc. (Rahway, NJ) |
Patent Claim Types:|
see list of patent claims
|Delivery; Device; Composition; |
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International Patent Family for Patent: 4,880,631
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