Generated: April 29, 2017
|Title:||Controlled porosity osmotic pump|
|Abstract:||The instant invention is directed to an osmotic pump, for the controlled release of diltiazem L-malate to an environment of use, said pump comprising: (A) a core which comprises a therapeutically effective amount of diltiazem L-malate and an effective buffering amount of sodium bitartrate surrounded by (B) a rate controlling water insoluble wall, having a fluid permeability of 6.96.times.10.sup.-18 to 6.96.times.10.sup.-14 cm.sup.3 sec/g and a reflection coefficient of less than 0.5, prepared from: (i) a polymer permeable to water but impermeable to solute and (ii) 0.1 to 60% by weight, based on the total weight of (i) and (ii), of at least one pH insensitive pore forming additive dispersed throughout said wall.|
|Inventor(s):||Haslam; John L. (Lawrence, KS), Rork; Gerald S. (Lawrence, KS)|
|Assignee:||Merck & Co., Inc. (Rahway, NJ)|
Patent Claim Types:|
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|Delivery; Device; Composition;|
|Country||Document Number||Estimated Expiration||Supplementary Protection Certificate||SPC Country||SPC Expiration|
|European Patent Office||0309051||► Subscribe|
|Hong Kong||47493||► Subscribe|
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