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Details for Patent: 4,880,631

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Summary for Patent: 4,880,631

Title: Controlled porosity osmotic pump
Abstract:The instant invention is directed to an osmotic pump, for the controlled release of diltiazem L-malate to an environment of use, said pump comprising: (A) a core which comprises a therapeutically effective amount of diltiazem L-malate and an effective buffering amount of sodium bitartrate surrounded by (B) a rate controlling water insoluble wall, having a fluid permeability of 6.96.times.10.sup.-18 to 6.96.times.10.sup.-14 cm.sup.3 sec/g and a reflection coefficient of less than 0.5, prepared from: (i) a polymer permeable to water but impermeable to solute and (ii) 0.1 to 60% by weight, based on the total weight of (i) and (ii), of at least one pH insensitive pore forming additive dispersed throughout said wall.
Inventor(s): Haslam; John L. (Lawrence, KS), Rork; Gerald S. (Lawrence, KS)
Assignee: Merck & Co., Inc. (Rahway, NJ)
Application Number:07/100,665
Patent Claim Types:
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Delivery; Device; Composition;

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International Patent Family for Patent: 4,880,631

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria73322► subscribe
Australia2277388► subscribe
Australia604564► subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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