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Generated: October 17, 2017

DrugPatentWatch Database Preview

Details for Patent: 4,873,259

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Summary for Patent: 4,873,259

Title: Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
Abstract:Compounds of the formula: ##STR1## wherein R.sub.1 is (1) hydrogen, (2) C.sub.1 to C.sub.4 alkyl, (3) C.sub.2 to C.sub.4 alkenyl, or (4) NR.sub.2 R.sub.3, wherein R.sub.2 and R.sub.3 are independently selected from (1) hydrogen, (2) C.sub.1 to C.sub.4 alkyl and (3) hydroxyl, but R.sub.2 and R.sub.3 are not simultaneously hydroxyl; wherein X is oxygen, sulfur, SO.sub.2, or NR.sub.4, wherein R.sub.4 is (1) hydrogen, (2) C.sub.1 to C.sub.6 alkyl, (3) C.sub.1 to C.sub.6 alkoyl, (4) aroyl, or (5) alkylsulfonyl; A is selected from C.sub.1 to C.sub.6 alkylene and C.sub.2 to C.sub.6 alkenylene; n is 1-5; Y is selected independently at each occurrence from (1) hydrogen, (2) halogen, (3) hydroxy, (4) cyano, (5) halosubstituted alkyl, (6) C.sub.1 to C.sub.12 alkyl, (7) C.sub.2 to C.sub.12 alkenyl, (8) C.sub.1 to C.sub.12 alkoxy, (9) C.sub.3 to C.sub.8 cycloalkyl, (10) C.sub.1 -C.sub.8 thioalkyl, (11) aryl, (12) aryloxy, (13) aroyl, (14) C.sub.1 to C.sub.12 arylalkyl, (15) C.sub.2 to C.sub.12 arylalkenyl, (16) C.sub.1 to C.sub.12 arylalkoxy, (17) C.sub.1 to C.sub.12 arylthioalkoxy, and substituted derivatives of (18) aryl, (19) aryloxy, (20) aroyl, (21) C.sub.1 to C.sub.12 arylalkyl, (22) C.sub.2 to C.sub.12 arylalkenyl, (23) C.sub.1 to C.sub.12 arylalkoxy, or (24) C.sub.1 to C.sub.12 arylthioalkoxy, wherein substituents are selected from halo, nitro, cyano, C.sub.1 to C.sub.12 alkyl, alkoxy, and halosubstituted alkyl; Z is oxygen or sulfur; and M is hydrogen, a pharmaceutically acceptable cation, aroyl, or C.sub.1 to C.sub.12 alkoyl, are potent inhibitors of 5- and/or 12-lipoxygenase enzymes. Also disclosed are lipoxygenase inhibiting compositions and a method for inhibiting lipoxygenase activity.
Inventor(s): Summers, Jr.; James B. (Libertyville, IL), Gunn; Bruce P. (Island Lake, IL), Brooks; Dee W. (Libertyville, IL)
Assignee: Abbott Laboratories (Abbott Park, IL)
Application Number:07/138,073
Patent Claim Types:
see list of patent claims
Compound; Use; Composition;

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International Patent Family for Patent: 4,873,259

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Australia631244► Subscribe
Australia6220190► Subscribe
Canada1306744► Subscribe
Canada1327204► Subscribe
Canada2024672► Subscribe
Germany3882732► Subscribe
Germany69029626► Subscribe
Denmark0416609► Subscribe
European Patent Office0279263► Subscribe
European Patent Office0416609► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
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