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Serving leading biopharmaceutical companies globally:

Boehringer Ingelheim
Federal Trade Commission
Express Scripts
Argus Health
Queensland Health

Generated: December 16, 2017

DrugPatentWatch Database Preview

Details for Patent: 4,866,168

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Summary for Patent: 4,866,168

Title: Hematoporphyrin derivatives and process of preparing
Abstract:To obtain tumor-selective, photosensitizing drugs useful in the localization of neoplastic tissue and treatment of abnormal neoplastic tissue such as tumors, one of two methods is used. In the first method, a hydrolyzed mixture of the products of reaction of hematoporphyrin with acetic acid and sulfuric acid is cycled through a microporous membrane system to exclude low molecular weight products. In the second method, drugs are synthesized or derived from other pyrrole compounds. The drugs: (1) include two covalently bound groups, each with four rings, some of which are pyrroles such as phlorins, porphyrins, chlorins, substituted pyrroles, substituted chlorins or substituted phlorins, each group being arranged in a ring structure, connected covalently to another group and have a triplet energy state above 37.5 kilocalories per mole; (2) are soluble in water, forming an aggregate of over 10,000 molecular weight in water and have an affinity for each other compared to serum protein such that 10 to 100 percent remain self aggregated in serum protein; and (3) are lipophyllic and able to disaggregate and attach to cell plasma, nuclear membrane, mitochondria, lysosomes and tissue. The drug obtained by the first method has an empirical formula of approximately C.sub.68 H.sub.70 N.sub.8 O.sub.11 or C.sub.68 H.sub.66 N.sub.8 O.sub.11 Na.sub.4. Neoplastic tissue retains the drug after it has cleared normal tissues and illumination results in necrosis. Moreover, other photosensitizing materials may be combined with a carrier that enters undesirable tissues and cells of the reticular endothelial system such as macrophages. These photosensitizing materials: (1) must have a triplet energy state above 3.5 kilocalories per mole; (2) cannot be easily oxidized; and (3) not physically quench any required energy state. Preferably, this photosensitizing material should be lipophlic.
Inventor(s): Dougherty; Thomas J. (Grand Island, NY), Potter; William R. (Grand Island, NY), Weishaupt; Kenneth R. (Sloan, NY)
Assignee: Health Research, Inc. (Buffalo, NY)
Application Number:06/889,829
Patent Claim Types:
see list of patent claims
Composition; Process; Use;

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International Patent Family for Patent: 4,866,168

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria53204► Subscribe
Australia2032283► Subscribe
Australia4246185► Subscribe
Australia581840► Subscribe
Australia588806► Subscribe
Canada1265450► Subscribe
Canada1271746► Subscribe
Canada1275452► Subscribe
China1011571► Subscribe
China85103992► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

Express Scripts
US Army
Cantor Fitzgerald
Boehringer Ingelheim
Queensland Health

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