Details for Patent: 4,863,970

Summary for Patent: 4,863,970

Title:	Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols
Abstract:	Penetration-enhancing pharmaceutical compositions for topical transepidermal and percutaneous application are disclosed which are non-irritating to the skin. These compositions are made up of a safe and effective amount of an active pharmaceutical permeant, including hydrophilic salt forms, contained in a novel penetration-enhancing vehicle comprising, (i) 1-95% w. of a cell-envelope disordering compound selected from the group consisting of oleic acid, oleyl alcohol, glycerol monoleate, glycerol dioleate, glycerol trioleate and mixtures thereof, (ii) 5-75% w., and preferably 5-49% w., of a lower alkanol selected from the group consisting of ethanol, propanol and isopropanol and mixtures thereof and (iii) 0-45% w., and preferably 1-45% w., of an inert diluent which, according to properties of the permeant used, may range from hydrophilic to hydrophobic. Water, polyethylene or polypropylene glycols and mineral oil are exemplary diluents.
Inventor(s):	Patel; Dinesh C. (Murray, UT), Chang; Yunik (Lakewood, NJ)
Assignee:	Theratech, Inc. (Salt Lake City, UT)
Application Number:	07/218,702
Patent Claim Types: see list of patent claims	Composition; Compound;

Drugs Protected by US Patent 4,863,970

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate

International Family Members for US Patent 4,863,970

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Austria	77559
Germany	3779999
European Patent Office	0267617
Spain	2042527
Greece	3005030