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Details for Patent: 4,863,970

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Summary for Patent: 4,863,970

Title: Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols
Abstract:Penetration-enhancing pharmaceutical compositions for topical transepidermal and percutaneous application are disclosed which are non-irritating to the skin. These compositions are made up of a safe and effective amount of an active pharmaceutical permeant, including hydrophilic salt forms, contained in a novel penetration-enhancing vehicle comprising, (i) 1-95% w. of a cell-envelope disordering compound selected from the group consisting of oleic acid, oleyl alcohol, glycerol monoleate, glycerol dioleate, glycerol trioleate and mixtures thereof, (ii) 5-75% w., and preferably 5-49% w., of a lower alkanol selected from the group consisting of ethanol, propanol and isopropanol and mixtures thereof and (iii) 0-45% w., and preferably 1-45% w., of an inert diluent which, according to properties of the permeant used, may range from hydrophilic to hydrophobic. Water, polyethylene or polypropylene glycols and mineral oil are exemplary diluents.
Inventor(s): Patel; Dinesh C. (Murray, UT), Chang; Yunik (Lakewood, NJ)
Assignee: Theratech, Inc. (Salt Lake City, UT)
Application Number:07/218,702
Patent Claim Types:
see list of patent claims
Composition; Compound;

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International Patent Family for Patent: 4,863,970

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria77559► subscribe
Germany3779999► subscribe
European Patent Office0267617► subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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