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Serving leading biopharmaceutical companies globally:

Harvard Business School
Queensland Health
US Department of Justice

Generated: November 23, 2017

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Details for Patent: 4,861,786

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Summary for Patent: 4,861,786

Title: Composition for a stable vein compatible injectable solution of torasemide process for the preparation and method of use
Abstract:The present invention provides an aqueous, alkaline injection solution of torasemide ready for injection, which contains a physiologically compatible alkaline buffer with a pH value of from 9.3 to 9.9 and with a buffer capacity of up to 0.1 val/liter together with an organic solvent in an amount of from 5 to 20% by weight selected from the group of polyethylene glycols with a molecular weight of from 100 to 1500, polypropylene glycols with a molecular weight of from 50 to 1000, glycerol, propylene glycol, ethanol and propanol, the torasemide being present in a concentration of from 2 to 40 mg/ml. Torasemide solutions are useful to inhibit inflammation or promote diuresis. The present invention also provides a process for the preparation of this solution, wherein torasemide is suspended in the above organic solvent brought into solution by the addition of aqueous alkali, adding the buffer and other adjuvants and adjusting the pH value to 9.3 to 9.9.
Inventor(s): Demmer; Fritz (Hirschberg-Leutershausen, DE), Gruber; Werner (Birkenau, DE), Woog; Heinrich (Laudenbach, DE)
Assignee: Boehringer Mannheim GmbH (Mannheim, DE)
Application Number:07/071,201
Patent Claim Types:
see list of patent claims
Composition; Formulation; Device; Process; Use;

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Foreign Priority and PCT Information for Patent: 4,861,786

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Germany3623620Jul 12, 1986

International Patent Family for Patent: 4,861,786

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria53296► Subscribe
Australia578562► Subscribe
Australia7535587► Subscribe
Canada1302278► Subscribe
Germany3623620► Subscribe
Germany3763010► Subscribe
Denmark174624► Subscribe
Denmark360287► Subscribe
European Patent Office0253226► Subscribe
Finland873059► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

Express Scripts
Queensland Health
Cantor Fitzgerald

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