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|Title:||Composition for a stable vein compatible injectable solution of torasemide process for the preparation and method of use|
|Abstract:||The present invention provides an aqueous, alkaline injection solution of torasemide ready for injection, which contains a physiologically compatible alkaline buffer with a pH value of from 9.3 to 9.9 and with a buffer capacity of up to 0.1 val/liter together with an organic solvent in an amount of from 5 to 20% by weight selected from the group of polyethylene glycols with a molecular weight of from 100 to 1500, polypropylene glycols with a molecular weight of from 50 to 1000, glycerol, propylene glycol, ethanol and propanol, the torasemide being present in a concentration of from 2 to 40 mg/ml. Torasemide solutions are useful to inhibit inflammation or promote diuresis. The present invention also provides a process for the preparation of this solution, wherein torasemide is suspended in the above organic solvent brought into solution by the addition of aqueous alkali, adding the buffer and other adjuvants and adjusting the pH value to 9.3 to 9.9.|
|Inventor(s):||Demmer; Fritz (Hirschberg-Leutershausen, DE), Gruber; Werner (Birkenau, DE), Woog; Heinrich (Laudenbach, DE)|
|Assignee:||Boehringer Mannheim GmbH (Mannheim, DE)|
Patent Claim Types:|
see list of patent claims
|Composition; Formulation; Device; Process; Use;|
|Foriegn Application Priority Data|
|Foreign Country||Foreign Patent Number||Foreign Patent Date|
|Germany||3623620||Jul 12, 1986|
|Country||Document Number||Estimated Expiration||Supplementary Protection Certificate||SPC Country||SPC Expiration|
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