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Serving leading biopharmaceutical companies globally:

Citi
Accenture
Argus Health
Medtronic
Federal Trade Commission
Julphar
Daiichi Sankyo
Novartis
Deloitte
Cipla

Generated: February 25, 2018

DrugPatentWatch Database Preview

Details for Patent: 4,861,786

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Summary for Patent: 4,861,786
Title: Composition for a stable vein compatible injectable solution of torasemide process for the preparation and method of use
Abstract:The present invention provides an aqueous, alkaline injection solution of torasemide ready for injection, which contains a physiologically compatible alkaline buffer with a pH value of from 9.3 to 9.9 and with a buffer capacity of up to 0.1 val/liter together with an organic solvent in an amount of from 5 to 20% by weight selected from the group of polyethylene glycols with a molecular weight of from 100 to 1500, polypropylene glycols with a molecular weight of from 50 to 1000, glycerol, propylene glycol, ethanol and propanol, the torasemide being present in a concentration of from 2 to 40 mg/ml. Torasemide solutions are useful to inhibit inflammation or promote diuresis. The present invention also provides a process for the preparation of this solution, wherein torasemide is suspended in the above organic solvent brought into solution by the addition of aqueous alkali, adding the buffer and other adjuvants and adjusting the pH value to 9.3 to 9.9.
Inventor(s): Demmer; Fritz (Hirschberg-Leutershausen, DE), Gruber; Werner (Birkenau, DE), Woog; Heinrich (Laudenbach, DE)
Assignee: Boehringer Mannheim GmbH (Mannheim, DE)
Application Number:07/071,201
Patent Claim Types:
see list of patent claims
Composition; Formulation; Device; Process; Use;

Drugs Protected by US Patent 4,861,786

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Foreign Priority and PCT Information for Patent: 4,861,786

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Germany3623620Jul 12, 1986

International Patents Family Members for US Patent 4,861,786

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria 53296 ➤ Sign Up
Australia 578562 ➤ Sign Up
Australia 7535587 ➤ Sign Up
Canada 1302278 ➤ Sign Up
Germany 3623620 ➤ Sign Up
Germany 3763010 ➤ Sign Up
Denmark 174624 ➤ Sign Up
Denmark 360287 ➤ Sign Up
European Patent Office 0253226 ➤ Sign Up
Finland 873059 ➤ Sign Up
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Covington
Medtronic
Teva
AstraZeneca
Merck
Argus Health
Deloitte
US Army
Cipla

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