Details for Patent: 4,777,163
✉ Email this page to a colleague
Summary for Patent: 4,777,163
Title: | Diphosphonate derivatives, pharmaceutical compositions and methods of use for calcium disturbances |
Abstract: | The present invention produces alkyldiphosphonic acid derivative of the general formula: ##STR1## wherein Het is a heteroaromatic five-membered ring containing to 3 heteroatoms which can be partly hydrogenated and optionally substituted one or more times by alkyl, alkoxy, phenyl, cyclohexyl, cyclohexylmethyl, halogen or amino, and two adjacent alkyl substituents can together also form a ring, Y is a hydrogen atom or a lower alkyl radical, X is a hydrogen atom, a hydroxyl group or an amino group optionally substituted by lower alkyl and R is a hydrogen atom or a lower alkyl radical, with the proviso that Het is not a pyrazole ring; as well as the pharmacologically acceptable salts thereof. The present invention also provides processes for the prepearation of these compounds and pharmaceutical compositions containing them useful for the treatment or prophylaxis of calcium metabolism disturbances or disease as for example osteoporosis, Bechterew's disease, bone metastases, urolithiasis, heterotropic ossifications, rheumatoid arthritis osteoarthritis or degenerative arthrosis. |
Inventor(s): | Bosies; Elmar (Weinheim, DE), Gall; Rudi (Hirschberg, DE) |
Assignee: | Boehringer Mannheim GmbH (Mannheim, DE) |
Application Number: | 07/077,228 |
Patent Claim Types: see list of patent claims | Compound; Use; Composition; |
Drugs Protected by US Patent 4,777,163
Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Patented / Exclusive Use | Submissiondate |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
>Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >Approval Date | >TE | >Type | >RLD | >RS | >Patent No. | >Patent Expiration | >Product | >Substance | >Delist Req. | >Patented / Exclusive Use | >Submissiondate |
Foreign Priority and PCT Information for Patent: 4,777,163
Foriegn Application Priority Data | ||
Foreign Country | Foreign Patent Number | Foreign Patent Date |
Germany | 3626058 | Aug 01, 1986 |
International Family Members for US Patent 4,777,163
Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
---|---|---|---|---|---|
Austria | 75748 | ⤷ Try a Trial | |||
Australia | 605778 | ⤷ Try a Trial | |||
Australia | 7625687 | ⤷ Try a Trial | |||
Canada | 1338895 | ⤷ Try a Trial | |||
Czechoslovakia | 266345 | ⤷ Try a Trial | |||
>Country | >Patent Number | >Estimated Expiration | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration |