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Generated: November 20, 2017

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Details for Patent: 4,704,282

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Summary for Patent: 4,704,282

Title: Transdermal therapeutic system having improved delivery characteristics
Abstract:A transdermal therapeutic system using a subsaturated matrix is provided having improved approved release characteristics. Reinforcing means preferably in the form of a fabric are embedded in the upper surface of the subsaturated matrix. At least a portion of the reinforcing means is selected such that the active agent to be delivered to the skin has a solubility, C.sub.r therein which is lower than the initial solubility C.sub.o of the agent in the matrix. In addition, the relationship between the diffusion coefficients of the agent in the matrix D.sub.m and the portion of reinforcing means D.sub.r and the solubilities is given by the relationship: D.sub.r .multidot.C.sub.r <D.sub.m .multidot.C.sub.o. In operation the agent dissolved in the reinforcing means acts as a secondary reservoir improving the release characteristics of the system. Specific embodiments of the invention are particularly adapted for scrotal and labial delivery of drugs such as testosterone and progesterone.
Inventor(s): Campbell; Patricia S. (Palo Alto, CA), Eckenhoff; James B. (Los Altos, CA)
Assignee: Alza Corporation (Palo Alto, CA)
Application Number:06/626,095
Patent Claim Types:
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International Patent Family for Patent: 4,704,282

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Germany3687067► Subscribe
European Patent Office0232580► Subscribe
Spain296615► Subscribe
Spain556380► Subscribe
Spain8706455► Subscribe
France2571623► Subscribe
United Kingdom8514446► Subscribe
United Kingdom2161073► Subscribe
United Kingdom8615106► Subscribe
Germany3523065► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

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