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Generated: September 19, 2017

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Title: Novel tri-phenyl alkane and alkene derivatives and their preparation and use
Abstract:The invention provides novel compounds of the formula: ##STR1## wherein n is 0 to 4, R.sub.1 and R.sub.2, which can be the same or different are H, OH, alkoxy of 1 to 4 carbon atoms, benzyloxy or methoxymethoxy; R.sub.3 is H, OH, halogen, alkoxy of 1 to 4 carbon atoms, benzyloxy, methoxymethoxy, 2,3-dihydroxypropoxy or ##STR2## wherein m is 1 or 2, R.sub.6 and R.sub.7, which can be the same or different are H or an alkyl group of 1 to 4 carbon atoms, or ##STR3## can form an N-containing three-, four-, five- or six-membered heterocyclic ring; R.sub.4 is OH, F, Cl, Br, I, mesyloxy, tosyloxy, alkylcarbonyloxy of 1 to 4 C-atoms, formyloxy or CH.sub.2 R.sub.4 is replaced by CHO; R.sub.5 is H or OH; or R.sub.4 and R.sub.5 together form an --O-- bridge between the carbon atoms to which they are attached, and their non-toxic pharmaceutically acceptable salts and esters and mixtures thereof. Processes for the preparation of these compounds are described, and also novel pharmaceutical compositions containing them. These compounds exhibit valuable pharmacological properties as estrogenic, anti-estrogenic, and progestanic agents. They are also effective against oestrogen-dependent tumors. Certain compounds are useful as chemical intermediates for the preparation of pharmacologically active compounds of the invention.
Inventor(s): Toivola; Reijo J. (Oulu, FI), Karjalainen; Arto J. (Oulu, FI), Kurkela; Kauko O. A. (Oulu, FI), Soderwall; Marja-Liisa (Oulu, FI), Kangas; Lauri V. M. (Turki, FI), Blanco; Guillermo L. (Oulu, FI), Sunduiqst; Hannu K. (Kaarina, FI)
Assignee: Farmos Group Ltd. (Turku, FI)
Application Number:06/823,856
Patent Claim Types:
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Compound; Use; Composition;

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Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom8218414Jun 25, 1982

International Patent Family for Patent: ► Subscribe

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria22064► Subscribe
Austria383344► Subscribe
AustriaA192983► Subscribe
Australia1494683► Subscribe
Australia556608► Subscribe
Bulgaria60760► Subscribe
Canada1185977► Subscribe
German Democratic Republic230864► Subscribe
Germany3366021► Subscribe
Denmark165785► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
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Serving 500+ biopharmaceutical companies globally:

Moodys
Queensland Health
AstraZeneca
Accenture
Medtronic
US Army
Daiichi Sankyo
Federal Trade Commission
Julphar
Cantor Fitzgerald

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