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|Title:||Diamide-DTPA-paramagnetic contrast agents for MR imaging|
|Abstract:||Homologs of Diamide-DTPA-Paramagnetic compounds (such as diamido acetyl diethylene triamine triacetic acid) provide excellent contrast agents for magnetic resonance (MR) imaging. The magnetic dipole generated by the unpaired electron within the paramagnetic (PM) atom, causes a local reduction in the bulk magnetic field of the MR system. The resulting shorting of the T1 (spin lattice) relaxation time in the local hydrogen protons within the area of interest, causes an intense "free induction signal" and a corresponding modulation in the collected scanning data. The tissue or organ of interest appears on the MR display highlighted in white. Background tissue is displayed as darker or lower intensity greys. A surface highlighted image of the small and large intestine may be obtained by venous injection of the diamide contrast agent. The contrast agent is formed by replacing two carboxylic acids on the DTPA chelator with functional amide groups. The homologs enable the Diamide-DTPA-PM contrast agents to go into solution readily, and promote organ selectivity.|
|Inventor(s):||Quay; Steven C. (Menlo Park, CA)|
|Assignee:||Salutar, Inc. (Sunnyvale, CA)|
Patent Claim Types:|
see list of patent claims
|Formulation; Composition; Compound; Use;|
|Country||Document Number||Estimated Expiration||Supplementary Protection Certificate||SPC Country||SPC Expiration|
|European Patent Office||0203962||<subscribe>|
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