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Serving leading biopharmaceutical companies globally:

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Generated: November 20, 2017

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Details for Patent: 4,687,659

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Summary for Patent: 4,687,659

Title: Diamide-DTPA-paramagnetic contrast agents for MR imaging
Abstract:Homologs of Diamide-DTPA-Paramagnetic compounds (such as diamido acetyl diethylene triamine triacetic acid) provide excellent contrast agents for magnetic resonance (MR) imaging. The magnetic dipole generated by the unpaired electron within the paramagnetic (PM) atom, causes a local reduction in the bulk magnetic field of the MR system. The resulting shorting of the T1 (spin lattice) relaxation time in the local hydrogen protons within the area of interest, causes an intense "free induction signal" and a corresponding modulation in the collected scanning data. The tissue or organ of interest appears on the MR display highlighted in white. Background tissue is displayed as darker or lower intensity greys. A surface highlighted image of the small and large intestine may be obtained by venous injection of the diamide contrast agent. The contrast agent is formed by replacing two carboxylic acids on the DTPA chelator with functional amide groups. The homologs enable the Diamide-DTPA-PM contrast agents to go into solution readily, and promote organ selectivity.
Inventor(s): Quay; Steven C. (Menlo Park, CA)
Assignee: Salutar, Inc. (Sunnyvale, CA)
Application Number:06/671,106
Patent Claim Types:
see list of patent claims
Formulation; Composition; Compound; Use;

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International Patent Family for Patent: 4,687,659

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Germany3590496► Subscribe
Germany3590578► Subscribe
European Patent Office0200750► Subscribe
European Patent Office0203962► Subscribe
United Kingdom2177086► Subscribe
United Kingdom2181428► Subscribe
United Kingdom8613493► Subscribe
United Kingdom8614549► Subscribe
Hong Kong6794► Subscribe
JapanH0645632► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

US Army
Johnson and Johnson
Daiichi Sankyo
Express Scripts

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