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Details for Patent: 4,621,077

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Summary for Patent: 4,621,077

Title: Pharmacologically active biphosphonates, process for the preparation thereof and pharmaceutical compositions therefrom
Abstract:Biphosphonic acids of general formula I: ##STR1## in which R is a fluorine atom of a linear or branched alkyl radical containing between 1 and 5 carbon atoms, which may also be substituted by one or more amino groups of fluorine atoms or both amino groups and fluorine atoms, R' is hydroxy or fluorine, and their salts with an alkali metal, an organic base or a basic aminoacid, exhibit valuable properties in the treatment of urolithiasis or in the treatment as inhibitors of bone reabsorption. The compound 4-amino-1-hydroxybutan-1,1-biphosphonic acid is between 100 and 300 times more active than Cl.sub.2 MDP.
Inventor(s): Rosini; Sergio (Pisa, IT), Staibano; Giorgio (Pisa, IT)
Assignee: Istituto Gentili S.p.A. (Pisa, IT)
Application Number:06/618,578
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Foreign Priority and PCT Information for Patent: 4,621,077

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Italy20781 A/82Apr 15, 1982

International Patent Family for Patent: 4,621,077

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Belgium896453► Subscribe
Switzerland661437► Subscribe
Germany19675047► Subscribe
Germany3313049► Subscribe
France2525223► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
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