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Serving leading biopharmaceutical companies globally:

Farmers Insurance
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Generated: November 17, 2017

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Details for Patent: 4,621,077

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Summary for Patent: 4,621,077

Title: Pharmacologically active biphosphonates, process for the preparation thereof and pharmaceutical compositions therefrom
Abstract:Biphosphonic acids of general formula I: ##STR1## in which R is a fluorine atom of a linear or branched alkyl radical containing between 1 and 5 carbon atoms, which may also be substituted by one or more amino groups of fluorine atoms or both amino groups and fluorine atoms, R' is hydroxy or fluorine, and their salts with an alkali metal, an organic base or a basic aminoacid, exhibit valuable properties in the treatment of urolithiasis or in the treatment as inhibitors of bone reabsorption. The compound 4-amino-1-hydroxybutan-1,1-biphosphonic acid is between 100 and 300 times more active than Cl.sub.2 MDP.
Inventor(s): Rosini; Sergio (Pisa, IT), Staibano; Giorgio (Pisa, IT)
Assignee: Istituto Gentili S.p.A. (Pisa, IT)
Application Number:06/618,578
Patent Claim Types:
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Foreign Priority and PCT Information for Patent: 4,621,077

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Italy20781 A/82Apr 15, 1982

International Patent Family for Patent: 4,621,077

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
JapanS58189193► Subscribe
Italy1201087► Subscribe
Italy8220781► Subscribe
Hong Kong79390► Subscribe
United Kingdom2118042► Subscribe
United Kingdom8308791► Subscribe
France2525223► Subscribe
Germany19675047► Subscribe
JapanH0213645► Subscribe
Germany3313049► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

Daiichi Sankyo
Federal Trade Commission
Chinese Patent Office
Boehringer Ingelheim

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