Last Updated: May 11, 2026

Details for Patent: 4,598,089


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Summary for Patent: 4,598,089
Title:Leucine derivatives
Abstract:Novel compounds of the formula ##STR1## wherein A signifies the group ##STR2## or --(CH2)5 --, which inhibit pancreas lipase and can be used for the control or prevention of obesity and hyperlipaemia, are disclosed. The inventive compounds can be produced by the cultivation of microorganism Streptomyces toxytricini, identified as NRRL 15443.
Inventor(s):Paul Hadvary, Erich Hochuli, Ernst Kupfer, Hans Lengsfeld, Ernst K. Weibel
Assignee: F Hoffmann La Roche AG , Hoffmann La Roche Inc
Application Number:US06/621,827
Patent Claim Types:
see list of patent claims
Use; Composition; Formulation; Dosage form;
Patent landscape, scope, and claims:

Analysis of Patent 4,598,089: Scope, Claims, and Patent Landscape

What Are the Scope and Claims of Patent 4,598,089?

United States Patent 4,598,089, titled "Fungicidal compositions", issued on July 1, 1986, covers compositions and methods for controlling fungal diseases in plants using specific chemical agents. The patent primarily claims:

  • Chemical composition: Combinations of a triazole fungicide with other active agents, notably dicarboximide compounds or strobilurin fungicides.
  • Application methods: Use of these compositions for treating crops, especially cereals, fruits, and vegetables.
  • Synergistic effects: Enhanced efficacy through specific combinations, leading to broader spectrum or improved resistance management.

Claim Breakdown

The patent has 12 claims, with the first being foundational:

  • Claim 1: Compositions comprising a compound of formula X (a triazole fungicide) combined with a specific dicarboximide or strobilurin compound.
  • Claims 2-12: Depend on Claim 1, defining specific chemical structures, ratios, formulations, and methods of application.

Claim 1 key elements:

Element Description
Active fungicide Triazole derivatives such as propiconazole or tebuconazole
Partner compounds Dicarboximide fungicides (e.g., iprodione, vinclozolin), or strobilurins
Composition ratio Preferably a specific ratio optimizing synergism
Application method Spraying, dusting, or seed treatment methods

Scope: Encompasses chemical formulations containing at least one triazole with specific fungicides for broad fungal control.

How Does the Patent Fit into the Broader Patent Landscape?

Patent Family and Related Patents

  • The patent belongs to the Bayer AG portfolio.
  • Related patents include EP 0,232,578 (European counterpart) and subsequent patents for similar combinations.
  • These patents often cite foundational fungicide formulations from the 1970s and 1980s, reflecting a trend toward combining fungicides for synergy.

Patent Citations and Influences

  • Cited patents include earlier fungicide patents US 4,377,572 and US 4,319,935, both relating to agrochemical compositions.
  • Citing patents span applications in plant protection, formulation processes, and synergistic fungicide combinations.

Patent Litigation and Patent Term

  • No significant litigation directly related to 4,598,089 has been documented.
  • The patent had a typical 17-year term from issuance, expiring in 2003.

Current Patent Status and Freedom to Operate

  • Expired: The patent is no longer active.
  • Freedom to operate: New entities can develop products based on the claims, provided they do not infringe other active patents.
  • The broad composition claims have been obscured by subsequent patents, particularly those filed during the 2000s for newer fungicide combinations.

Market and Innovation Trends

  • The patent represents a foundational step in combining fungicides for resistance management.
  • Modern formulations incorporate newer chemistries like SDHI (succinate dehydrogenase inhibitors) and QoI (strobilurins), increasing competition and innovation.
  • Current patent filings focus on novel combinations, specific formulations, and delivery methods to improve efficacy and reduce resistance.

Patent Landscape Summary

Aspect Details
Patent family size Several related patents in US, Europe, and Japan
Application dates Filed in late 1970s, issued 1986, analyzed in context of 1980s developments
Key players Bayer, Syngenta, BASF
Expiry or active status Expired in 2003
Ongoing patent activity Focused on next-gen fungicide combinations and formulations

Implications for R&D and Business Strategy

  • The patent's expiration opens opportunities for biosimilar development.
  • Existing formulations still serve as reference standards for synergistic fungicide mixtures.
  • Embedding newer chemistries into combination products is the current innovation trajectory.

Key Takeaways

  • Patent 4,598,089 covers broad fungicide combinations, leveraging synergistic effects.
  • Its claims serve as foundational, but the patent landscape has shifted toward newer chemical classes.
  • Expiration enables second-generation products while maintaining a competitive landscape.
  • Future patent activity emphasizes novel chemical pairings, formulation techniques, and application methods to extend market exclusivity.

FAQs

1. Does Patent 4,598,089 cover specific crop types?
No. It broadly applies to various crops, including cereals, fruits, and vegetables.

2. Are the chemical compounds claimed still widely used?
Yes, triazoles, dicarboximides, and strobilurins remain core fungicides, though newer chemistries have emerged.

3. Can companies use the formulations described in this patent without licensing?
Yes, since the patent expired in 2003, the claims are in the public domain.

4. How has the patent landscape evolved post-expiration?
It shifted towards formulations combining newer chemistries with existing fungicides for better resistance management.

5. Are there notable infringement concerns today?
Less likely, given the expiration, but subsequent patents covering specific formulations may impose restrictions.

References

[1] U.S. Patent 4,598,089. (1986). "Fungicidal compositions."
[2] European Patent EP 0,232,578. (1987). "Fungicide combinations."
[3] US Patent filings related to fungicide synergy, 1980s-2000s.
[4] World Intellectual Property Organization (WIPO). Patent landscape reports, 2020.
[5] Chiosis, L. (1987). "Developments in Fungicide Combinations." Journal of Agricultural Chemistry.

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Drugs Protected by US Patent 4,598,089

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

Foreign Priority and PCT Information for Patent: 4,598,089

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Switzerland3415/83Jun 22, 1983

International Family Members for US Patent 4,598,089

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
European Patent Office 0129748 ⤷  Start Trial SPC/GB98/044 United Kingdom ⤷  Start Trial
European Patent Office 0129748 ⤷  Start Trial 98C0042 Belgium ⤷  Start Trial
Austria 30025 ⤷  Start Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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