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Details for Patent: 4,559,332

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Summary for Patent: 4,559,332

Title: 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof
Abstract:Steroid compounds of the 20-spiroxane series and their analogues having an open ring E of the formula, ##STR1## in which --A--A-- represents the group --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--, R.sup.1 represents hydrogen, and R.sup.2 represents an .alpha.-oriented lower alkoxycarbonyl radical, or R.sup.1 and R.sup.2 together represent an .alpha.- or a .beta.-oriented methylene radical, --B--B-- represents the group --CH.sub.2 --CH.sub.2 -- or an .alpha.- or .beta.-oriented group ##STR2## X represents two hydrogen atoms or oxo, Y.sup.1 and Y.sup.2 together represent the oxygen bridge --O--, or Y.sup.1 represents hydroxy, and Y.sup.2 represents hydroxy, lower alkoxy or, if X represents H.sub.2, also lower alkanoyloxy, and salts of compounds in which X represents oxo and Y.sup.2 represents hydroxy, are distinguished as effective aldosterone-antagonists with minimal side-effects and, for that reason, are especially suitable for the treatment of all forms of hyperaldosteronism.
Inventor(s): Grob; Jurgen (Giebenach, CH), Kalvoda; Jaroslav (Binningen, CH)
Assignee: Ciba Geigy Corporation (Ardsley, NY)
Application Number:06/598,109
Patent Claim Types:
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Compound; Composition; Use;

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Foreign Priority and PCT Information for Patent: 4,559,332

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Switzerland1981/83Apr 13, 1983

International Patent Family for Patent: 4,559,332

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Denmark189484<disabled in preview>
Germany122004000012<disabled in preview>
German Democratic Republic251144<disabled in preview>
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