Details for Patent: 4,559,332

Summary for Patent: 4,559,332

Title:	20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof
Abstract:	Steroid compounds of the 20-spiroxane series and their analogues having an open ring E of the formula, ##STR1## in which --A--A-- represents the group --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--, R.sup.1 represents hydrogen, and R.sup.2 represents an .alpha.-oriented lower alkoxycarbonyl radical, or R.sup.1 and R.sup.2 together represent an .alpha.- or a .beta.-oriented methylene radical, --B--B-- represents the group --CH.sub.2 --CH.sub.2 -- or an .alpha.- or .beta.-oriented group ##STR2## X represents two hydrogen atoms or oxo, Y.sup.1 and Y.sup.2 together represent the oxygen bridge --O--, or Y.sup.1 represents hydroxy, and Y.sup.2 represents hydroxy, lower alkoxy or, if X represents H.sub.2, also lower alkanoyloxy, and salts of compounds in which X represents oxo and Y.sup.2 represents hydroxy, are distinguished as effective aldosterone-antagonists with minimal side-effects and, for that reason, are especially suitable for the treatment of all forms of hyperaldosteronism.
Inventor(s):	Grob; Jurgen (Giebenach, CH), Kalvoda; Jaroslav (Binningen, CH)
Assignee:	Ciba Geigy Corporation (Ardsley, NY)
Application Number:	06/598,109
Patent Claim Types: see list of patent claims	Compound; Composition; Use;

Drugs Protected by US Patent 4,559,332

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate

Foreign Priority and PCT Information for Patent: 4,559,332

Foriegn Application Priority Data
Foreign Country	Foreign Patent Number	Foreign Patent Date
Switzerland	1981/83	Apr 13, 1983

International Family Members for US Patent 4,559,332

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Argentina	241918
Argentina	242221
Argentina	242222