|Title:||Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine|
|Abstract:||Novel cis-isomeric derivatives of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine are useful as antidepressant agents. These novel compounds act to block the synaptosomal uptake of serotonin (5-hydroxy-tryptamine), thereby alleviating serotonin abnormalities at central receptor sites. The preferred embodiment is the enantiomer cis-(1S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenam ine and its pharmaceutically acceptable acid addition salts.|
|Inventor(s):||Welch, Jr.; Willard M. (Mystic, CT), Harbert; Charles A. (Waterford, CT), Koe; B. Kenneth (Gales Ferry, CT), Kraska; Allen R. (East Lyme, CT)|
|Assignee:||Pfizer Inc. (New York, NY)|
Patent Claim Types:|
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|Compound; Use; Composition;|
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