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Serving leading biopharmaceutical companies globally:

Harvard Business School
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Generated: October 23, 2017

DrugPatentWatch Database Preview

Details for Patent: 4,525,358

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Summary for Patent: 4,525,358

Title: 2-[4-(Diphenylmethyl)-1-piperazinyl]-acetic acids and their amides
Abstract:New 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids, their amides and their salts, processes for the preparation thereof and therapeutic compositions. These compounds have the formula ##STR1## wherein Y=--OH or --NH.sub.2 ; X and X'=H, halogen, alkoxy or trifluoromethyl; m=1 or 2 and n=1 or 2. The amides of the 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids are prepared either by reacting a 1-(diphenylmethyl)-piperazine with an omegahaloacetamide, or by reacting an alkali metal salt of an omega-[4-(diphenylmethyl)-1-piperazinyl]-alkanol with a 2-haloacetamide, or yet by reacting ammonia with a halide or alkyl ester of a 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acid, whereas the 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids are prepared by hydrolyzing the corresponding amide or lower alkyl ester. These compounds have in particular an antiallergic, spasmolytic and antihistaminic activity.
Inventor(s): Baltes; Eugene (Rhode-St.Genese, BE), de Lannoy; Jean (Brussels, BE), Rodriguez; Ludovic (Brussels, BE)
Assignee: UCB Pharmaceuticals, Inc. (Dover, DE)
Application Number:06/496,489
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;

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Foreign Priority and PCT Information for Patent: 4,525,358

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom8103768Feb 06, 1981
United Kingdom8110990Apr 08, 1981

International Patent Family for Patent: 4,525,358

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Denmark155796► Subscribe
Denmark5388► Subscribe
European Patent Office0058146► Subscribe2001C/045Belgium► Subscribe
European Patent Office0058146► SubscribeSPC/GB01/052United Kingdom► Subscribe
Finland75816► Subscribe
Spain521548► Subscribe
Spain8307776► Subscribe
Spain509358► Subscribe
Denmark44082► Subscribe
Denmark154078► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

Federal Trade Commission
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