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Serving leading biopharmaceutical companies globally:

Cerilliant
Daiichi Sankyo
McKinsey
Accenture
Healthtrust
US Department of Justice
Novartis
Dow
McKesson
Cantor Fitzgerald

Generated: January 21, 2018

DrugPatentWatch Database Preview

Details for Patent: 4,346,227

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Summary for Patent: 4,346,227
Title: ML-236B Derivatives and their preparation
Abstract:Compounds of formula (I): ##STR1## (wherein R represents a group of formula ##STR2## and the corresponding ring-closed lactones, salts (especially alkali metal salts) and esters (especially C.sub.1 -C.sub.5 alkyl esters) thereof may be prepared by subjecting ML-236B, or ML-236B carboxylic acid or a salt or ester thereof to enzymatic hydroxylation, which may be effected by means of microorganisms of the genera Mucor, Rhizopus, Zygorynchus, Circinella, Actinomucor, Gongronella, Phycomyces, Martierella, Pycnoporus, Rhizoctonia, Absidia, Cunninghamella, Syncephalastrum and Streptomyces, or cell-free, enzyme-containing extracts from said microorganisms. The compounds are capable of inhibiting biosynthesis of cholesterol and are thus useful in the treatment of hypercholesteraemia.
Inventor(s): Terahara; Akira (Hiromachi, JP), Tanaka; Minoru (Hiromachi, JP)
Assignee: Sankyo Company, Limited (Tokyo, JP)
Application Number:06/270,846
Patent Claim Types:
see list of patent claims
Compound;

Drugs Protected by US Patent 4,346,227

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Foreign Priority and PCT Information for Patent: 4,346,227

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Japan55-76127Jun 06, 1980
Japan55-115483Aug 22, 1980
Japan55-124385Sep 08, 1980
Japan55-130311Sep 19, 1980

International Patents Family Members for US Patent 4,346,227

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria 374495 ➤ Subscribe
Austria A256781 ➤ Subscribe
Australia 549988 ➤ Subscribe
Australia 7137681 ➤ Subscribe
Belgium 889150 ➤ Subscribe
Canada 1150170 ➤ Subscribe
Switzerland 655090 ➤ Subscribe
Germany 3122499 ➤ Subscribe
Denmark 149080 ➤ Subscribe
Denmark 247081 ➤ Subscribe
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving leading biopharmaceutical companies globally:

US Department of Justice
Chubb
UBS
McKinsey
Moodys
Deloitte
Queensland Health
Daiichi Sankyo
AstraZeneca

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