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Serving leading biopharmaceutical companies globally:

Cantor Fitzgerald
US Department of Justice
Queensland Health

Generated: November 19, 2017

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Details for Patent: 4,346,227

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Summary for Patent: 4,346,227

Title: ML-236B Derivatives and their preparation
Abstract:Compounds of formula (I): ##STR1## (wherein R represents a group of formula ##STR2## and the corresponding ring-closed lactones, salts (especially alkali metal salts) and esters (especially C.sub.1 -C.sub.5 alkyl esters) thereof may be prepared by subjecting ML-236B, or ML-236B carboxylic acid or a salt or ester thereof to enzymatic hydroxylation, which may be effected by means of microorganisms of the genera Mucor, Rhizopus, Zygorynchus, Circinella, Actinomucor, Gongronella, Phycomyces, Martierella, Pycnoporus, Rhizoctonia, Absidia, Cunninghamella, Syncephalastrum and Streptomyces, or cell-free, enzyme-containing extracts from said microorganisms. The compounds are capable of inhibiting biosynthesis of cholesterol and are thus useful in the treatment of hypercholesteraemia.
Inventor(s): Terahara; Akira (Hiromachi, JP), Tanaka; Minoru (Hiromachi, JP)
Assignee: Sankyo Company, Limited (Tokyo, JP)
Application Number:06/270,846
Patent Claim Types:
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Foreign Priority and PCT Information for Patent: 4,346,227

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Japan55-76127Jun 06, 1980
Japan55-115483Aug 22, 1980
Japan55-124385Sep 08, 1980
Japan55-130311Sep 19, 1980

International Patent Family for Patent: 4,346,227

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Italy8167777► Subscribe
Finland71168► Subscribe
Finland811762► Subscribe
Spain8300353► Subscribe
Spain502827► Subscribe
Denmark149080► Subscribe
Denmark247081► Subscribe
Germany3122499► Subscribe
Switzerland655090► Subscribe
France2483912► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

Queensland Health
US Department of Justice
Daiichi Sankyo
US Army

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