Details for Patent: 4,346,227
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Summary for Patent: 4,346,227
Title: | ML-236B Derivatives and their preparation |
Abstract: | Compounds of formula (I): ##STR1## (wherein R represents a group of formula ##STR2## and the corresponding ring-closed lactones, salts (especially alkali metal salts) and esters (especially C.sub.1 -C.sub.5 alkyl esters) thereof may be prepared by subjecting ML-236B, or ML-236B carboxylic acid or a salt or ester thereof to enzymatic hydroxylation, which may be effected by means of microorganisms of the genera Mucor, Rhizopus, Zygorynchus, Circinella, Actinomucor, Gongronella, Phycomyces, Martierella, Pycnoporus, Rhizoctonia, Absidia, Cunninghamella, Syncephalastrum and Streptomyces, or cell-free, enzyme-containing extracts from said microorganisms. The compounds are capable of inhibiting biosynthesis of cholesterol and are thus useful in the treatment of hypercholesteraemia. |
Inventor(s): | Terahara; Akira (Hiromachi, JP), Tanaka; Minoru (Hiromachi, JP) |
Assignee: | Sankyo Company, Limited (Tokyo, JP) |
Application Number: | 06/270,846 |
Patent Claim Types: see list of patent claims | Compound; |
Drugs Protected by US Patent 4,346,227
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Foreign Priority and PCT Information for Patent: 4,346,227
International Family Members for US Patent 4,346,227
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Austria | 374495 | ⤷ Try a Trial | |||
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