Details for Patent: 4,278,654
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Summary for Patent: 4,278,654
| Title: | Process for the preparation of a sterile injectable physiologically acceptable solution of an X-ray contrast agent and solutions of the X-ray contrast agent and a buffer |
| Abstract: | Sterile, injectable, physiologically acceptable solutions of an X-ray contrast agent are prepared by autoclaving a solution of a m-carboxamido-o-iodo-N-(β-hydroxyalkyl)aniline X-ray contrast agent in the presence of a physiologically acceptable buffer system the pH of which decreases with increasing temperature. The presence of a temperature dependent buffer, preferably an amine, enables X-ray contrast agents to be sterilized by autoclaving without significant decomposition. Examples of the autoclaving processes are given and solutions for autoclaving containing a m-carboxamido-o-iodo-N-(β-hydroxyalkyl)aniline X-ray contrast agent and a physiologically acceptable buffer system the pH of which decreases with increasing temperature are described and claimed. |
| Inventor(s): | Fridtjov B. Rakli, Michael J. Kelly |
| Assignee: | GE Healthcare AS, Norgas AS |
| Application Number: | US06/054,440 |
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Patent Claim Types: see list of patent claims | Compound; Process; |
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Drugs Protected by US Patent 4,278,654
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Patented / Exclusive Use | Submissiondate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| >Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >Approval Date | >TE | >Type | >RLD | >RS | >Patent No. | >Patent Expiration | >Product | >Substance | >Delist Req. | >Patented / Exclusive Use | >Submissiondate |
Foreign Priority and PCT Information for Patent: 4,278,654
| Foriegn Application Priority Data | ||
| Foreign Country | Foreign Patent Number | Foreign Patent Date |
| United Kingdom | 28764/78 | Jul 4, 1978 |
International Family Members for US Patent 4,278,654
| Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
|---|---|---|---|---|---|
| Argentina | 222337 | ⤷ Start Trial | |||
| Austria | 371998 | ⤷ Start Trial | |||
| Austria | A464479 | ⤷ Start Trial | |||
| Australia | 4861579 | ⤷ Start Trial | |||
| Australia | 523295 | ⤷ Start Trial | |||
| Belgium | 877443 | ⤷ Start Trial | |||
| Canada | 1132901 | ⤷ Start Trial | |||
| >Country | >Patent Number | >Estimated Expiration | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration |
