Generated: December 10, 2017
DrugPatentWatch Database Preview
Details for Patent: 4,277,479
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Summary for Patent: 4,277,479
|Title:|| Tetrazolylalkoxycarbostyril derivatives and pharmaceutical compositions containing them|
|Abstract:||Novel tetrazolylalkoxycarbostyril derivative of the formula (I): ##STR1## wherein R.sup.1 is a hydrogen atom, a lower alkyl group, a low alkenyl group, a lower alkanoyl group, a benzoyl group or phenylalkyl group; R.sup.2 is a hydrogen atom, a lower alkyl group or a group of the formula ##STR2## R.sup.3 is a lower alkyl group, a cycloalkyl group, a cycloalkylalkyl group, a phenyl group or a phenylalkyl group; A is a lower alkylene group; the carbon-carbon bond between 3- and 4-positions in the carbostyril skeleton is either single or double bond; and the substituted position of a group of the formula, ##STR3## in the carbostyril skeleton is either 4-, 5-, 6-, 7- or 8-position provided that the only one such group of the formula can be substituted in the whole carbostyril skeleton, thus when R.sup.2 in 4-position is a group of the formula ##STR4## then 5-, 6-, 7- or 8-position will have no such substituted group; furthermore, the phenyl group in the above-mentioned benzoyl group, phenylalkyl group or phenyl group may have substituted group(s). The above-mentioned novel tetrazolylalkoxycarbostyril derivatives have pharmacological activities such as platelet aggregation inhibitory action, antiinflammatory action, antiulcer action, vasodilatory action and phosphodiesterase inhibitory action and are useful as anti-thrombosis agent, cerebral blood flow improving agent, antiinflammatory agent, antiulcer agent, anti-hypertensive agent and anti-asthmatic agent.|
|Inventor(s):|| Nishi; Takao (Tokushima, JP), Nakagawa; Kazuyuki (Tokushima, JP) |
|Assignee:|| Otsuka Pharmaceutical Co., Ltd. (Tokyo, JP) |
Patent Claim Types:|
see list of patent claims
|Compound; Composition; |
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Foreign Priority and PCT Information for Patent: 4,277,479
|Foriegn Application Priority Data|
||Foreign Patent Number
||Foreign Patent Date
|Japan||53/107869||Sep 01, 1978|
International Patent Family for Patent: 4,277,479
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