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|Title:||Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone|
|Abstract:||Nonapeptide and decapeptide analogs of LH-RH of the formula and the pharmaceutically acceptable salts thereof wherein: V is tryptophyl, phenylalanyl or 3-(1-naphthyl)-L-alanyl; W is tyrosyl, phenylalanyl or 3-(1-pentafluorophenyl)-L-alanyl; X is a D-amino acid residue ##STR1## wherein R is (a) a carbocyclic aryl-containing radical selected from the group consisting of naphthyl, anthryl, fluorenyl, phenanthryl, biphenylyl, benzhydryl and phenyl substituted with three or more straight chain lower alkyl groups; or (b) a saturated carbocyclic radical selected from the group consisting of cyclohexyl substituted with three or more straight chain lower alkyl groups, perhydronaphthyl, perhydrobiphenylyl, perhydro-2,2-diphenylmethyl and adamantyl; Y is leucyl, isoleucyl, nor-leucyl or N-methyl-leucyl; Z is glycinamide or --NH--R.sup.1, wherein R.sup.1 is lower alkyl, cycloalkyl, fluoro lower alkyl or ##STR2## wherein R.sup.2 is hydrogen or lower alkyl, are disclosed. These compounds exhibit potent LH-RH agonist properties.|
|Inventor(s):||Nestor; John J. (San Jose, CA), Jones; Gordon H. (Cupertino, CA), Vickery; Brian H. (Cupertino, CA)|
|Assignee:||Syntex (U.S.A.) Inc. (Palo Alto, CA)|
Patent Claim Types:|
see list of patent claims
|Compound; Use; Composition;|
|Country||Document Number||Estimated Expiration||Supplementary Protection Certificate||SPC Country||SPC Expiration|
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