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Serving leading biopharmaceutical companies globally:

Deloitte
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Harvard Business School
Dow
AstraZeneca
Merck
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Generated: January 20, 2018

DrugPatentWatch Database Preview

Details for Patent: 4,234,571

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Summary for Patent: 4,234,571
Title: Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone
Abstract:Nonapeptide and decapeptide analogs of LH-RH of the formula and the pharmaceutically acceptable salts thereof wherein: V is tryptophyl, phenylalanyl or 3-(1-naphthyl)-L-alanyl; W is tyrosyl, phenylalanyl or 3-(1-pentafluorophenyl)-L-alanyl; X is a D-amino acid residue ##STR1## wherein R is (a) a carbocyclic aryl-containing radical selected from the group consisting of naphthyl, anthryl, fluorenyl, phenanthryl, biphenylyl, benzhydryl and phenyl substituted with three or more straight chain lower alkyl groups; or (b) a saturated carbocyclic radical selected from the group consisting of cyclohexyl substituted with three or more straight chain lower alkyl groups, perhydronaphthyl, perhydrobiphenylyl, perhydro-2,2-diphenylmethyl and adamantyl; Y is leucyl, isoleucyl, nor-leucyl or N-methyl-leucyl; Z is glycinamide or --NH--R.sup.1, wherein R.sup.1 is lower alkyl, cycloalkyl, fluoro lower alkyl or ##STR2## wherein R.sup.2 is hydrogen or lower alkyl, are disclosed. These compounds exhibit potent LH-RH agonist properties.
Inventor(s): Nestor; John J. (San Jose, CA), Jones; Gordon H. (Cupertino, CA), Vickery; Brian H. (Cupertino, CA)
Assignee: Syntex (U.S.A.) Inc. (Palo Alto, CA)
Application Number:06/047,661
Patent Claim Types:
see list of patent claims
Compound; Use; Composition;

Drugs Protected by US Patent 4,234,571

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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International Patents Family Members for US Patent 4,234,571

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Japan S55164663 ➤ Subscribe
Italy 8022519 ➤ Subscribe
Italy 1149971 ➤ Subscribe
Denmark 79384 ➤ Subscribe
Denmark 152734 ➤ Subscribe
Denmark 248880 ➤ Subscribe
Denmark 149046 ➤ Subscribe
European Patent Office 0021234 ➤ Subscribe SPC/GB93/056 United Kingdom ➤ Subscribe
European Patent Office 0021234 ➤ Subscribe 93C0049 Belgium ➤ Subscribe
Spain 492289 ➤ Subscribe
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving leading biopharmaceutical companies globally:

Boehringer Ingelheim
US Army
Novartis
McKinsey
Citi
Johnson and Johnson
Colorcon
Dow
Deloitte

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