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Details for Patent: 4,234,571

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Summary for Patent: 4,234,571

Title: Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone
Abstract:Nonapeptide and decapeptide analogs of LH-RH of the formula and the pharmaceutically acceptable salts thereof wherein: V is tryptophyl, phenylalanyl or 3-(1-naphthyl)-L-alanyl; W is tyrosyl, phenylalanyl or 3-(1-pentafluorophenyl)-L-alanyl; X is a D-amino acid residue ##STR1## wherein R is (a) a carbocyclic aryl-containing radical selected from the group consisting of naphthyl, anthryl, fluorenyl, phenanthryl, biphenylyl, benzhydryl and phenyl substituted with three or more straight chain lower alkyl groups; or (b) a saturated carbocyclic radical selected from the group consisting of cyclohexyl substituted with three or more straight chain lower alkyl groups, perhydronaphthyl, perhydrobiphenylyl, perhydro-2,2-diphenylmethyl and adamantyl; Y is leucyl, isoleucyl, nor-leucyl or N-methyl-leucyl; Z is glycinamide or --NH--R.sup.1, wherein R.sup.1 is lower alkyl, cycloalkyl, fluoro lower alkyl or ##STR2## wherein R.sup.2 is hydrogen or lower alkyl, are disclosed. These compounds exhibit potent LH-RH agonist properties.
Inventor(s): Nestor; John J. (San Jose, CA), Jones; Gordon H. (Cupertino, CA), Vickery; Brian H. (Cupertino, CA)
Assignee: Syntex (U.S.A.) Inc. (Palo Alto, CA)
Application Number:06/047,661
Patent Claim Types:
see list of patent claims
Compound; Use; Composition;

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International Patent Family for Patent: 4,234,571

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
JapanS55164663► subscribe
Italy8022519► subscribe
Italy1149971► subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
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