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Last Updated: April 18, 2024

Details for Patent: 4,201,211


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Summary for Patent: 4,201,211
Title: Therapeutic system for administering clonidine transdermally
Abstract:Therapeutic system in the form of a skin patch that administers clonidine transdermally in an initial priming dose of 10 to 300 mcg/cm.sup.2 of skin that brings the concentration of clonidine in the blood to a level sufficient to elicit alpha-adrenergic stimulation without intolerable side effects, followed by a substantially constant continuous dosage in the range of 0.1 to 100 mcg/hr that maintains said level. The system is a four-layer laminate of, from the top: a protective backing; a gelled, mineral oil-polyisobutene-clonidine reservoir lamina that is the source of the clonidine for the continuous constant dosage; a microporous membrane that controls the constant dosage rate; and a gelled, mineral oil-polyisobutene-clonidine contact adhesive layer that is the source of the clonidine for the priming dose and the means by which the system is attached to the skin.
Inventor(s): Chandrasekaran; Santosh K. (Palo Alto, CA), Darda; Siegfried (Ingelheim am Rhein, DE), Michaels; Alan S. (Atherton, CA), Cleary; Gary W. (Palo Alto, CA)
Assignee: ALZA Corporation (Palo Alto, CA) Boehringer Ingelheim GmbH (Ingelheim am Rhein, DE)
Application Number:05/815,033
Patent Claim Types:
see list of patent claims
Composition;

Drugs Protected by US Patent 4,201,211

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 4,201,211

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Argentina 218037 ⤷  Try a Trial
Austria 362884 ⤷  Try a Trial
Austria A905877 ⤷  Try a Trial
Australia 2846277 ⤷  Try a Trial
Australia 512328 ⤷  Try a Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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