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Generated: October 24, 2017

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Details for Patent: 4,021,481

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Summary for Patent: 4,021,481

Title: Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups
Abstract:This invention relates to novel X-ray contrast agents particularly for use in the cerebrospinal cavities, comprising non-ionic alkanols carrying at least one N-bonded secondary or tertiary amide group and having at least two hydroxyl groups and at least one iodine atom in the molecule. Particularly useful compounds include the N-hydroxyalkyl iodoalkane sulphonamides having at least two hydroxyl groups, tri- and tetra-iodobenzene carrying carbamoyl, acylamino and/or acylaminomethyl substituents and having at least two hydroxyl groups in the molecule and at least one N-hydroxyalkyl group. Particularly preferred compounds comprise 2,4,6-triiodobenzamides which may be 3- and/or 5-substituted with a variety of groups. The compounds all show markedly low toxicities and a number show very high levels of water solubility.
Inventor(s): Almen; Torsten (Oslo, NO), Haavaldsen; Johan (Oslo, NO), Nordal; Vegard (Oslo, NO)
Assignee: Nyegaard & Co. A/S (Oslo, NO)
Application Number:05/528,842
Patent Claim Types:
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Foreign Priority and PCT Information for Patent: 4,021,481

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
32699/69Jun 27, 1969
6130/70Feb 9, 1970

International Patent Family for Patent: 4,021,481

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria318134► Subscribe
Belgium752574► Subscribe
Brazil7020080► Subscribe
Canada935153► Subscribe
Switzerland544551► Subscribe
Germany2031724► Subscribe
Denmark130709► Subscribe
Spain381202► Subscribe
Finland53066► Subscribe
France2053037► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

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