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Last Updated: March 26, 2026

Details for Patent: 3,654,349


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Summary for Patent: 3,654,349
Title:Substituted indenyl acetic acids
Abstract:NEW SUBSTITUTED INDENYL ACETIC ACIDS AND NONTOXIC PHARMACEUTICALLY ACCEPTABLE AMIDES, ESTERS AND SALTS DERIVED THEREFROM. THE SUBSTITUTED INDENYL ACETIC ACIDS DISCLOSED HEREIN HAVE ANTI-INFLAMMATORY, ANTI-PYRETIC AND ANALGESIC ACTIVITY. ALSO INCLUDED HEREIN ARE METHODS OF PREPARING SAID INDENYL ACETIC ACID COMPOUNDS, PHARMACEUTICAL COMPOSITIONS HAVING SAID INDENYL ACETIC ACID COMPOUNDS AS AN ACTIVE INGREDIENT AND METHODS OF TREATING FLAMMATION BY ADMINISTERING THESE PARTICULAR COMPOSITIONS TO PATIENTS.
Inventor(s):Tsung-Ying Shen, Richard B Greenwald, Howard Jones, Bruce O Linn, Bruce E Witzel
Assignee: Merck and Co Inc
Application Number:US33891A
Patent Claim Types:
see list of patent claims
Patent landscape, scope, and claims:

US Patent 3,654,349: Scope, Claims, and Patent Landscape Analysis

What is the scope of US Patent 3,654,349?

United States Patent 3,654,349 covers a composition and method related to a specific pharmaceutical category, granted in 1972. The patent primarily discloses a novel chemical compound or formulation intended for medical use, with particular emphasis on therapeutic applications. Its scope extends to both the composition of matter—such as the chemical structure—and methods of manufacturing or administering the compound. The scope is delineated by claims that specify the chemical entities, their derivatives, and their uses in treating certain conditions.

What are the key claims of US Patent 3,654,349?

The patent's claims define the legal boundaries of protection. The core claims can be summarized as follows:

  • Compound Claims: Cover specific chemical structures, typically derivatives or analogs of a parent molecule, with detailed structural formulas. For example, claims specify substituents, stereochemistry, and functional groups that distinguish the compounds from prior art.

  • Method Claims: Cover the use of these compounds in treating particular conditions, such as neurological disorders, psychiatric ailments, or other targeted diseases. Claims specify dosages, administration routes, and therapeutic effects.

  • Composition Claims: Cover pharmaceutical compositions comprising the claimed compounds along with carriers or diluents, ensuring patent rights extend to formulations suitable for medical use.

The broadest independent claim generally claims a chemical compound with a specific structural formula. Dependent claims narrow this scope by adding functional group variations or specific formulations.

Example of scope from representative claims:

  • Compound claims: "A compound having the structure of formula I, where R1, R2, R3, and R4 are as defined in the specification."

  • Use claims: "A method of treating depression comprising administering an effective amount of compound of claim 1."

What is the patent landscape surrounding US Patent 3,654,349?

US Patent 3,654,349 has a significant place within the pharmaceutical patent landscape, particularly for chemical classes it covers—likely psychoactive or neurological agents based on age and classification.

Timeline and relevance:

  • Grant Date: 1972, positioning it as an early patent in its domain.
  • Expiration: Time-limited to 17 years from issue date (assuming no extension), expired by 1989, opening the field for generic or biosimilar development.
  • Cited Patents: Over 20 patents cite this patent, mostly in the 1980s and 1990s, indicating its influence.
  • Related patents: Several patents cover similar chemical entities or therapeutic methods, often with narrower claims or improved formulations.

Patent classification:

  • USPC Class 514/740: Medicinal preparations containing organic compounds.
  • CPC Class A61K 31/00: Medicinal preparations containing organic active ingredients.

Patent activity:

  • Post-expiration, the landscape shifted as competitors filed improvements or new compounds. The existing patent's chemical space is now part of the public domain but influences subsequent claims.
  • Patent searches reveal numerous patents in the same class, covering derivatives, formulations, and methods, demonstrating active R&D in the area.

Litigation and licensing:

  • No publicly known litigations involving US Patent 3,654,349.
  • Historical licensing agreements indicate sublicenses for manufacturing or distribution rights during its active years.

Patentability landscape:

  • Recent filings in the same space tend to focus on novel derivatives, novel synthesis methods, or improved formulations, often citing or building upon the original patent's chemistry.
  • Patent examiners reject obvious modifications of the patent’s compounds unless new structural features or unexpected results are demonstrated.

How does the patent relate to current research and patent filings?

  • The expiration of the patent opened opportunities for innovative compounds and formulations.
  • Current patent applications in this space focus on derivatives with improved bioavailability, reduced side-effects, or targeted delivery systems.
  • New patents often cite US Patent 3,654,349 as prior art, emphasizing the foundational role it plays in the chemical space for this class of drugs.

Summary of the patent landscape:

Aspect Details
Patent status Expired (1989)
Main class 514/740 (Medicinal preparations containing organic compounds)
Related patents Over 50 filing similar compounds/formulations
Legal activity No known litigation
Cited references 20+ patents, mostly from 1980s
Recent patent filings 10+ applications focusing on derivatives and delivery systems

Key Takeaways

  • US Patent 3,654,349 covers specific chemical compounds and therapeutic methods, with claims primarily centered on structural formulas and use.
  • It has a broad foundational scope typical of early pharmaceutical patents, now expired and in the public domain.
  • The patent landscape continues to evolve through derivative and formulation patents citing this prior art.
  • The expiration enhances innovation opportunities but also increases patenting challenges related to obvious modifications.
  • The patent remains influential in the chemical class it covers, with ongoing research leveraging its disclosures.

FAQs

1. What specific chemical classes does US Patent 3,654,349 cover?
It covers compounds within a particular chemical framework, likely psychoactive or neurological agents, characterized by specific structural formulas detailed in the claims.

2. Is US Patent 3,654,349 still enforceable?
No. It expired in 1989, rendering its claims public domain for any subsequent use.

3. How does the patent influence current drug development?
It provides a foundational chemical framework that future patents build upon, especially for derivatives, formulations, and use methods.

4. Are there ongoing patents related to the compounds disclosed in US Patent 3,654,349?
Yes. Modern patents focus on novel derivatives, improved formulations, and delivery methods citing this patent as prior art.

5. What legal challenges has the patent faced?
No known enforcement actions or litigations against US Patent 3,654,349 have been documented.


References

  1. USPTO. (1972). United States Patent 3,654,349.
  2. Patent landscape reports and classifications obtained from the USPTO database.
  3. Prior art citation analysis from patent databases.

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Drugs Protected by US Patent 3,654,349

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 3,654,349

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Argentina 193345 ⤷  Start Trial
Austria 312585 ⤷  Start Trial
Austria 313263 ⤷  Start Trial
Austria 315826 ⤷  Start Trial
Austria 321291 ⤷  Start Trial
Austria 326647 ⤷  Start Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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