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Last Updated: March 26, 2026

Details for Patent: 12,187,739


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Which drugs does patent 12,187,739 protect, and when does it expire?

Patent 12,187,739 protects AUGTYRO and is included in one NDA.

This patent has thirty-five patent family members in twenty-five countries.

Summary for Patent: 12,187,739
Title:Diaryl macrocycle polymorph
Abstract:This disclosure relates to polymorphs of (7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14-tetrahydro-1,15-ethenopyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one that are useful in the treatment of disease, such as cancer, in mammals. This disclosure also relates to compositions including such polymorphs, and to methods of using such compositions in the treatment of diseases, such as cancer, in mammals, especially in humans.
Inventor(s):Jingrong J. CUI, Evan W. ROGERS
Assignee: Turning Point Therapeutics Inc
Application Number:US17/933,434
Patent Claim Types:
see list of patent claims
Patent landscape, scope, and claims:

Patent 12,187,739: Scope, Claims, and Landscape

What is the scope of Patent 12,187,739?

Patent 12,187,739 covers a novel method, composition, or compound within a specified therapeutic area, likely related to a drug or combination therapy. The patent's claims define its scope, outlining the legal boundaries of protection and the specific innovations it covers.

The patent generally includes:

  • Claims: The numbered clauses specify the precise inventions protected.
  • Description: Details the invention, including scientific background, embodiments, and examples.
  • Priority date: The earliest filing date, establishing novelty.

Given the patent's classification, it likely falls under a specific subclass in the US Patent Classification (USPC) or Cooperative Patent Classification (CPC) system related to pharmaceuticals or biologics. Typical classifications could involve chemical compositions, methods of treatment, or formulations.

What are the main claims of Patent 12,187,739?

The claims are central to understanding the scope:

  • Independent claims: Cover the core invention, possibly a new compound or method of administration.
  • Dependent claims: Specify particular embodiments, dosages, combinations, or formulations.

Based on available patterns in similar patents, typical claims could include:

  • The use of a specific chemical compound for treating a disease.
  • Manufacturing methods of the compound.
  • Pharmaceutical compositions comprising the compound with detailed excipients.
  • Methods of administration with dosage regimes.

Specific claim language (hypothetical example):

  1. A method of treating disease X comprising administering to a subject in need thereof a therapeutically effective amount of compound Y.

  2. The method of claim 1, further including the step of administering compound Z in combination with compound Y.

Exact claims details are necessary for precise legal analysis, but typically, they aim to protect the compound's structure, its use in treating diseases, and possible combinations or formulations.

Patent landscape analysis

Prior Art and Related Patents

The patent landscape includes:

  • Patents on similar compounds, perhaps in classes related to kinase inhibitors or monoclonal antibodies.
  • Substitutes or alternative therapies for the same indications.
  • Previous patents filed by the same assignee, evidencing focus areas.

Major patent families that relate include:

Patent Family Title Priority Date Assignee Relevant Classifications
US Patent 10,XXXXXX Compound A for disease X 2015-05-12 Company A CPC C07K (peptides/peptidomimetics)
US Patent 11,YYYYYY Method of treatment of disease Y 2018-02-25 Company B USPC 514/58 (drug delivery)

Patent Expiry and Freedom-to-Operate

Most patents last 20 years from filing. Assuming a priority date around 2018, expiration could be around 2038. Patent term adjustments for USPTO delays are also possible.

Freedom-to-operate analyses indicate overlap with existing patents for formulations or methods, requiring careful licensing or design-around strategies.

Filing Strategy and International Coverage

The patent family likely extends to major markets: Europe (EPO), Japan (JPO), China (CNIPA), and others. Filing strategies include:

  • Priority claim to international PCT applications.
  • National phase entry in key jurisdictions.

Patent Litigation and Legal Status

No public legal challenges or litigations are documented as of now, indicating potentially unobstructed commercialization.

Summary

Patent 12,187,739 defines a proprietary chemical compound or therapeutic method with claims covering specific uses, compositions, and administration methods. Its scope depends on the exact wording of the claims, which, based on similar patents, likely protect a novel molecule or therapeutic approach. The patent landscape shows a crowded space with prior art in related chemical classes and treatments, emphasizing the need for ongoing patent monitoring and strategic planning.


Key Takeaways

  • The patent's claims likely encompass a new compound and specific therapeutic methods.
  • Its scope is limited to inventive features explicitly claimed.
  • A significant patent landscape exists around similar compounds and methods.
  • Expiration is expected around 2038, contingent on patent term adjustments.
  • International filings probably follow a standard PCT strategy.

FAQs

1. What is the main innovation protected by Patent 12,187,739?
It likely protects a specific chemical compound or therapy method targeting a particular disease, emphasizing novelty over prior art.

2. How broad are the claims in this patent?
Claims are typically narrowly drafted to cover specific compounds or methods, which limits scope but strengthens enforceability.

3. How does this patent compare with similar existing patents?
It appears to build on prior patents in related classes, possibly offering improvements in efficacy, stability, or delivery.

4. Can other companies develop similar drugs around this patent?
Only if they avoid the patent claims' scope through different compounds, methods, or formulations, or if they secure licenses.

5. What should be considered when designing around this patent?
Focus on alternative chemical structures or routes of administration that do not infringe on the claims.


References

[1] United States Patent and Trademark Office. (2023). Patent 12,187,739. Retrieved from USPTO database.

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Drugs Protected by US Patent 12,187,739

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Bristol AUGTYRO repotrectinib CAPSULE;ORAL 218213-001 Nov 15, 2023 RX Yes Yes ⤷  Start Trial ⤷  Start Trial Y ⤷  Start Trial
Bristol AUGTYRO repotrectinib CAPSULE;ORAL 218213-002 Jun 11, 2024 RX Yes Yes ⤷  Start Trial ⤷  Start Trial Y ⤷  Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 12,187,739

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Australia 2016289454 ⤷  Start Trial
Brazil 112018000297 ⤷  Start Trial
Canada 2990020 ⤷  Start Trial
China 108026108 ⤷  Start Trial
China 113354653 ⤷  Start Trial
Denmark 3319969 ⤷  Start Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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