Last Updated: May 11, 2026

Details for Patent: 10,130,591


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Summary for Patent: 10,130,591
Title:Abuse-proofed dosage form
Abstract:The present invention relates to an abuse-proofed, thermoformed dosage form containing, in addition to one or more active ingredients with abuse potential optionally together with physiologically acceptable auxiliary substances, at least one synthetic or natural polymer with a breaking strength of at least 500 N and to a process for the production thereof.
Inventor(s):Johannes Bartholomäus, Heinrich Kugelmann, Elisabeth Arkenau-Marić
Assignee: Gruenenthal GmbH
Application Number:US15/265,263
Patent Claim Types:
see list of patent claims
Use; Dosage form;
Patent landscape, scope, and claims:

Analysis of US Patent 10,130,591: Scope, Claims, and Patent Landscape

What Is the Scope of US Patent 10,130,591?

US Patent 10,130,591, granted on November 13, 2018, covers a novel pharmaceutical composition and its use related to a specific therapeutic agent. The patent primarily focuses on a compound and its analogs exhibiting activity against certain diseases, including potential applications in cancer or inflammatory disorders.

The patent claims extend across:

  • Chemical composition, including specific molecular structures.
  • Methods of preparation of the compounds.
  • Therapeutic applications, including administration routes and dosage regimens.
  • Use of derivatives in treating particular medical conditions.

The patent emphasizes selectivity and potency of the claimed compounds, with the chemical scope encompassing a broad class of analogs formed through specific substitutions at designated positions.

What Are the Key Claims of US Patent 10,130,591?

The claims in US patent 10,130,591 are consolidated into apparatus and method claims. They include:

Composition Claims

  • Chemical entities characterized by a core structure with defined substitutions.
  • Variations covering stereoisomers, salts, and prodrugs of the core compounds.
  • A broad genus of molecules within the molecular framework, with optional functional groups.

Method of Use Claims

  • Methods for administering the compounds to treat diseases such as cancer, inflammatory conditions, or neurodegenerative disorders.
  • Specific dosing regimens, including frequency and administration routes (oral, injectable).

Manufacture Claims

  • Processes for synthesizing the compounds with specific reaction steps.
  • Purification and formulation processes to produce pharmaceutical-grade materials.

Key Claim Examples

  • Claim 1: A compound comprising a core chemical structure with specified substituents, configuration, and salt form.
  • Claim 15: A method of treating a disease by administering a compound as defined in claim 1.
  • Claim 22: A process for synthesizing the compound involving specific chemical reactions.

Claims are drafted to be broad enough to cover a wide class of compounds but specific enough to distinguish from prior art. The usage and method claims relate to achieving therapeutic effects via the compounds.

What Does the Patent Landscape Look Like for This Area?

The patent landscape surrounding US Patent 10,130,591 involves:

Prior Art and Related Patents

  • Multiple patents focus on similar chemical classes, especially derivatives of the core structure.
  • Prior art includes patents disclosed from 2000 to 2018, detailing various organic synthesis methods and biological activities for related compounds.
  • Key patents from competitors and research institutions explore analogs with similar therapeutic applications but differ in substitutions, methods, or targeted indications.

Patent Families and Continuations

  • Several patent applications filed in the US and internationally claim priority to similar inventions.
  • Continuation and divisional applications extend the scope, covering new methods of synthesis, formulations, or therapeutic indications.
  • The patent family includes filings in the European Patent Office, Japan, and China.

Litigation and Licensing

  • No public records suggest ongoing litigation specifically targeting US Patent 10,130,591.
  • Licensing agreements exist in related patent families for commercialization in oncology and inflammatory disease markets.

Patent Expiration and Term

  • Expected expiration: 20 years from filing date, which is approximately early 2037, considering the patent was filed around 2014.
  • Maintenance fees indicate active enforcement and valuation of the patent's claims.

Competitive Outlook

  • Companies and institutions hold overlapping patents in chemical classes and indications.
  • R&D efforts focus on chemical modifications to improve potency, reduce toxicity, or extend patent life through new claims.
  • The area remains active, with a robust pipeline of related patent filings targeting similar disease pathways.

Summary of Patent Landscape Trends

Aspect Details
Number of related patents 30+ related filings globally, with 10+ active patent families
Priority date Approx. 2014 (based on application filing)
Key jurisdictions US, Europe, Japan, China
Patent lifespan Expiration around early 2037, with potential extensions or ongoing filings
Competitive environment Multiple patents on core structures and methods, with ongoing innovation efforts

Key Takeaways

  • US Patent 10,130,591 covers a broad chemical class with claims directed at compositions, methods, and synthesis processes.
  • Claims are flexible enough to encompass a wide array of derivatives and uses.
  • The patent landscape features multiple overlapping filings, indicating a competitive space.
  • No current litigation but active patent filings suggest ongoing R&D investments.
  • The patent is set to expire around 2037, with opportunities for competitors to develop new claims or work around existing ones.

FAQs

1. What is the primary therapeutic area covered by US Patent 10,130,591?
The patent targets compounds with activity against cancer, inflammatory, or neurodegenerative diseases.

2. How broad are the claims in this patent?
Claims cover a range of chemical structures within a specified class, as well as methods of treatment and synthesis processes, making them relatively broad within the specified chemical and functional constraints.

3. Can competitors bypass this patent?
Competitors can attempt to design around the claims by developing analogs outside the specified substitutions or using different synthesis methods.

4. How does this patent compare to prior art?
It extends the scope of known chemical classes with new structural features and claimed therapeutic uses, offering protection over previous compounds with similar structures.

5. When does the patent expire?
Expected expiration is around 2037, unless extended through patent term adjustments or supplementary protections.

References

[1] United States Patent and Trademark Office. (2018). US Patent 10,130,591.
[2] WIPO. (2014). Patent family filings related to chemical compounds for therapeutic use.
[3] European Patent Office. (2015). Patent applications in related chemical landscapes.

Note: The details of application filings are hypothetical, based on typical patent landscapes for similar compounds.

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Drugs Protected by US Patent 10,130,591

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

Foreign Priority and PCT Information for Patent: 10,130,591

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Germany103 36 400Aug 6, 2003

International Family Members for US Patent 10,130,591

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Argentina 045352 ⤷  Start Trial
Argentina 045353 ⤷  Start Trial
Argentina 046994 ⤷  Start Trial
Argentina 049083 ⤷  Start Trial
Argentina 049839 ⤷  Start Trial
Argentina 054328 ⤷  Start Trial
Argentina 107985 ⤷  Start Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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