Details for Patent: 10,085,992

Which drugs does patent 10,085,992 protect, and when does it expire?

Patent 10,085,992 protects COSELA and is included in one NDA.

This patent has fifty-four patent family members in eighteen countries.

Summary for Patent: 10,085,992

Title:	Transient protection of normal cells during chemotherapy
Abstract:	This invention is in the area of improved compounds, compositions and methods of transiently protecting healthy cells, and in particular hematopoietic stem and progenitor cells (HSPC) as well as renal cells, from damage associated with DNA damaging chemotherapeutic agents. In one aspect, improved protection of healthy cells is disclosed using disclosed compounds that act as highly selective and short, transiently-acting cyclin-dependent kinase 4/6 (CDK 4/6) inhibitors when administered to subjects undergoing DNA damaging chemotherapeutic regimens for the treatment of proliferative disorders.
Inventor(s):	Strum; Jay Copeland (Hillsborough, NC), Bisi; John Emerson (Apex, NC), Roberts; Patrick Joseph (Durham, NC), Tavares; Francis Xavier (Durham, NC)
Assignee:	G1 Therapeutics, Inc. (Research Triangle Park, NC)
Application Number:	15/342,990
Patent Claim Types: see list of patent claims	Use;

Analyzing the Scope and Claims of United States Patent 10,085,992

Introduction

United States Patent 10,085,992, titled "Transient protection of normal cells during chemotherapy," is an invention that focuses on improving compounds, compositions, and methods to protect healthy cells, particularly hematopoietic stem cells, during chemotherapy. Here, we will delve into the details of the patent's scope, claims, and the broader patent landscape.

Patent Overview

The patent, assigned the number US10085992B2, was granted to protect a specific method and composition designed to transiently safeguard normal cells from the harmful effects of chemotherapy. This invention is crucial in the field of oncology, as it aims to reduce the side effects of chemotherapy on healthy cells.

Claims

The claims of a patent are the most critical part, as they define the scope of the invention and what is protected by the patent.

Independent Claims

• The patent includes several independent claims that outline the core aspects of the invention. For example, Claim 1 might describe a composition comprising specific compounds that provide transient protection to normal cells during chemotherapy[4].

Dependent Claims

• Dependent claims further specify the details of the independent claims. These could include the specific types of compounds, the method of administration, and the duration of protection[4].

Scope of the Invention

The scope of the invention is defined by the claims and the detailed description provided in the patent.

Protected Compounds and Compositions

• The patent protects specific compounds and compositions that are designed to transiently protect normal cells. These compounds may include inhibitors of cell cycle regulators, such as CDK4 inhibitors, which play a role in protecting hematopoietic stem cells[4].

Methods of Protection

• The methods described include the administration of these compounds before, during, or after chemotherapy to ensure the protection of healthy cells. The patent may also specify the dosage and timing of the administration[4].

Patent Landscape

Understanding the patent landscape is essential to grasp the position of this patent within the broader intellectual property ecosystem.

Prior Art

• The patent cites prior art related to cell protection during chemotherapy, including other compounds and methods that have been previously disclosed. The prior art section helps in distinguishing the current invention from existing technologies[4].

Related Patents

• Other patents in the same field, such as those related to cancer treatment and cell protection, are part of the broader patent landscape. For instance, patents on therapeutic combinations for treating specific cancers or protecting cells during different types of treatments are relevant[5].

International Patent Offices and Global Dossier

To understand the global reach of this patent, it is important to look at international patent offices and the Global Dossier service.

Global Dossier

• The Global Dossier service, provided by the USPTO, allows users to view the file histories of related applications from participating IP Offices. This can help in identifying if similar patents have been filed in other countries and the status of those applications[1].

International Patent Databases

• Databases such as those provided by the European Patent Office (EPO), Japan Patent Office (JPO), and the World Intellectual Property Organization (WIPO) can be used to search for similar patents filed internationally[1].

Search Tools and Resources

Several tools and resources are available to conduct a thorough search related to this patent.

Patent Public Search

• The USPTO's Patent Public Search tool is a powerful resource for searching prior art and related patents. It provides enhanced access to prior art and can be used to find similar inventions[1].

Common Citation Document (CCD)

• The CCD application consolidates citation data from participating IP Offices, making it easier to visualize the prior art cited by different offices for the same invention[1].

Economic and Statistical Analysis

The USPTO provides datasets and research papers that can help in analyzing the economic and statistical aspects of patent claims.

Patent Claims Research Dataset

• This dataset, provided by the USPTO, contains detailed information on claims from US patents and patent applications. It can be used to analyze the scope and trends of patent claims over time[3].

Practical Implications

Understanding the scope and claims of this patent has practical implications for researchers, pharmaceutical companies, and healthcare providers.

Research and Development

• Researchers can use the information from this patent to develop new methods and compounds for protecting healthy cells during chemotherapy. This can lead to more effective and safer cancer treatments[4].

Licensing and Collaboration

• Pharmaceutical companies may be interested in licensing this technology or collaborating with the patent holders to bring these protective compounds to market[4].

Key Takeaways

• Patent Scope: The patent protects specific compounds and methods for transiently protecting normal cells during chemotherapy.
• Claims: The claims define the core aspects of the invention, including the composition and method of administration.
• Patent Landscape: The patent is part of a broader landscape that includes other patents related to cancer treatment and cell protection.
• International Reach: The Global Dossier and international patent databases can help in understanding the global status of similar patents.
• Search Tools: Tools like the Patent Public Search and CCD are essential for conducting thorough searches.
• Economic Analysis: The Patent Claims Research Dataset can be used to analyze the economic and statistical aspects of patent claims.

FAQs

1. What is the main purpose of United States Patent 10,085,992?

   • The main purpose is to protect compounds and methods designed to transiently protect normal cells, particularly hematopoietic stem cells, during chemotherapy.

2. How can I search for similar patents internationally?

   • You can use databases provided by international patent offices such as the EPO, JPO, and WIPO, as well as the Global Dossier service.

3. What tools are available for searching prior art related to this patent?

   • The USPTO's Patent Public Search tool and the Common Citation Document (CCD) application are powerful resources for searching prior art.

4. How can I analyze the economic and statistical aspects of this patent?

   • The USPTO's Patent Claims Research Dataset provides detailed information on claims from US patents and patent applications, which can be used for economic and statistical analysis.

5. What are the practical implications of this patent for pharmaceutical companies?

   • Pharmaceutical companies can use this patent to develop new treatments, license the technology, or collaborate with the patent holders to bring these protective compounds to market.

Sources

1. USPTO - Search for patents
2. DrugPatentWatch - Patent 10,085,992
3. USPTO - Patent Claims Research Dataset
4. Google Patents - US10085992B2
5. Unified Patents - US-20170246171-A1

Drugs Protected by US Patent 10,085,992

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate
Pharmacosmos	COSELA	trilaciclib dihydrochloride	POWDER;INTRAVENOUS	214200-001	Feb 12, 2021		RX	Yes	Yes	10,085,992					A METHOD TO DECREASE THE INCIDENCE OF CHEMOTHERAPY-INDUCED MYELOSUPPRESSION IN ADULT PATIENTS WHEN ADMINISTERED PRIOR TO A CARBOPLATIN AND ETOPOSIDE-CONTAINING REGIMEN FOR EXTENSIVE-STAGE SMALL CELL LUNG CANCER

International Family Members for US Patent 10,085,992

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Canada	2906156
Canada	2906157
Canada	2906166
Canada	3152117
China	105407723
China	105407889