Details for Patent: 6,388,074
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Title: | Process for the preparation of purine derivatives |
Abstract: | The present invention provides a process for the synthesis of penciclovir and famciclovir by 9-substituting 2-amino-6-chloropurine (ACP) with an appropriate side chain precursor, followed by conversion of the 6-chloro moiety to a hydroxy moiety (i.e. to form a guanine) or hydrogen (to form a 2-aminopurine), respectively. |
Inventor(s): | Geen; Graham Richard (Dunmow, GB), Jarvest; Richard Lewis (Ware, GB) |
Assignee: | Novartis International Pharmaceutical Ltd. (Hamilton, BM) |
Filing Date: | Dec 11, 2000 |
Application Number: | 09/734,051 |
Claims: | 1. A process for the preparation of i) penciclovir or ii) famciclovir which process comprises: i) hydrolysing 9-(4-acetoxy-3-acetoxymethylbut-1-yl)-2-amino-6-chloropurine to give penciclovir; or ii) reducing 9-(4-acetoxy-3-acetoxymethylbut-1-yl)-2-amino-6-chloropurine to give famciclovir. 2. A compound known as 9-(4-acetoxy-3-acetoxymethylbutyl)-2-amino-6-chloropurine. |