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|Title:||Process for the preparation of purine derivatives|
|Abstract:||The present invention provides a process for the synthesis of penciclovir and famciclovir by 9-substituting 2-amino-6-chloropurine (ACP) with an appropriate side chain precursor, followed by conversion of the 6-chloro moiety to a hydroxy moiety (i.e. to form a guanine) or hydrogen (to form a 2-aminopurine), respectively.|
|Inventor(s):||Geen; Graham Richard (Dunmow, GB), Jarvest; Richard Lewis (Ware, GB)|
|Assignee:||Novartis International Pharmaceutical Ltd. (Hamilton, BM)|
|Filing Date:||Dec 11, 2000|
|Claims:||1. A process for the preparation of i) penciclovir or ii) famciclovir which process comprises: |
i) hydrolysing 9-(4-acetoxy-3-acetoxymethylbut-1-yl)-2-amino-6-chloropurine to give penciclovir; or
ii) reducing 9-(4-acetoxy-3-acetoxymethylbut-1-yl)-2-amino-6-chloropurine to give famciclovir.
2. A compound known as 9-(4-acetoxy-3-acetoxymethylbutyl)-2-amino-6-chloropurine.
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