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Serving leading biopharmaceutical companies globally:

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Generated: November 23, 2017

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Title: Analgesic agent and its use
Abstract:Aqueous pharmaceutical compositions comprising levobupivacaine((S)-1-butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide ), that are particularly useful in a patient who is disposed to adverse systemic side-effects, are disclosed.
Inventor(s): Bardsley; Hazel Judith (Cambridge, GB), Gristwood; Robert William (Cambridge, GB), Richards; Andrew John McGlashan (Cambridge, GB)
Assignee: Darwin Discovery, Ltd. (GB)
Filing Date:Dec 14, 1998
Application Number:09/210,966
Claims:1. A pharmaceutical composition comprising a solution of at least 0.75% w/v of levobupivacaine, measured as the free base; wherein the concentration of levobupivacaine is less than 2% w/v; and wherein said levobupivacaine is present in at least a 90% enantiomeric excess with respect to dexbupivacaine.

2. The composition, according to claim 1, wherein the concentration of levobupivacaine is in the range of from 0.75% to 1.5% w/v.

3. The composition, according to claim 2, wherein the concentration of levobupivacaine is selected from the group consisting of 0.75%, 1%, 1.25%, and 1.5% w/v.

4. The composition, according to claim 1, which is an aqueous solution.

5. The composition, according to claim 1, wherein the levobupivacaine is substantially free of dexbupivacaine.

6. A unit dose of levobupivacaine comprising an ampoule containing a composition according to claim 1.

7. The unit dose, according to claim 6, containing 1 to 15 ml of the composition.

8. A pharmaceutical composition comprising a solution of 0.75% w/v of levobupivacaine, measured as the free base; and wherein said levobupivacaine is present in at least a 90% enantiomeric excess with respect to dexbupivacaine.
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Cipla
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Daiichi Sankyo
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Healthtrust
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US Army
Moodys

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