Generated: May 28, 2017
|Title:||Process for the preparation of purine derivatives|
|Abstract:||The present invention provides a process for the synthesis of penciclovir and famciclovir by 9-substituting the compound 2-amino-6-chloropurine (ACP) with 2-acetoxymethyl-4-(leaving group)-but-1-yl acetate, followed by displacement of the 6-chloro moiety with a hydroxy moiety (i.e. to form a guanine derivative) or with hydrogen (to form the 2-aminopurine derivative), respectively.|
|Inventor(s):||Geen; Graham Richard (Stansted Mountfitchet, GB2), Jarvest; Richard Lewis (Surbiton, GB2)|
|Assignee:||Beecham Group plc (Brentford, GB)|
|Filing Date:||Jun 10, 1994|
|Claims:||1. A process for the preparation of i) penciclovir or ii) famciclovir which process comprises the reaction of 2-amino-6-chloropurine with 2-acetoxymethyl-4-(leaving group)-but-1-yl acetate; |
to give 9-(4-acetoxy-3-acetoxymethylbut-1-yl)-2-amino-6-chloropurine;
i) hydrolysing to give penciclovir:
ii) reducing to give famciclovir.
2. A process according to claim 1 wherein the leaving group is halo.
3. A process according to claim 2 wherein the halogen is chlorine.
4. A process according to claim 2 wherein the halogen is bromine.
5. A process according to claim 2 wherein the halogen is iodine.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.