|Title:||Benzofuran 2-carbox amides useful as inhibitors of leukoriene biosynthesis|
|Abstract:||Compounds of the Formula I: ##STR1## and pharmaceutically acceptable salts thereof are inhibitors of leukotriene biosynthesis. These compounds inhibit the mammalian 5-lipoxygenase enzyme, thus preventing the metabolism of arachidonic acid to the leukotrienes. These compounds are thus useful in the treatment of asthma, allergic disorders, inflammation, skin diseases and certain cardiovascular disorders.|
|Inventor(s):||Atkinson; Joseph G. (Montreal, CA), Guindon; Yvan (Ile Bizard, CA), Lau; Cheuk K. (Pierrefonds, CA)|
|Assignee:||Merck Frosst Canada, Inc. (Kirkland, CA)|
|Filing Date:||Jan 30, 1989|
|Claims:||1. A compound of the Formula: ##STR9## wherein the substituents for compound are selected from the following groups: |
2. A method of inhibiting mammalian leukotriene biosynthesis or action which comprises administering to a mammal in need of such treatment a pharmaceutically effective amount of a compound of claim 1.
3. A method of claim 2 wherein the mammal is a human.
4. A method of treating pulmonary conditions, inflammation, allergies, pain, cardiovascular conditions, or skin conditions which comprises administering to a human in need of such treatment a pharmaceutically effective amount of a compound of claim 1.
5. A pharmaceutical composiiton useful for inhibiting the ibosynthesis of mammalian leukotrienes comprising a pharmaceuticlaly acceptable carrier and an effective amount of a compound of claim 1.