Last Updated: June 17, 2026

Details for Patent: 4,831,157

✉ Email this page to a colleague

« Back to Dashboard

Title:	Preparation of angiotensin-converting enzyme inhibitors
Abstract:	Novel compounds with angiotensin-converting enzyme inhibitory activity are disclosed. Such compounds are useful in the treatment of cardiovascular disorders, especially hypertension and congestive heart failure, and are useful in the treatment of glaucoma. Also disclosed is a novel process for preparing intermediates useful in the preparation of the claimed compounds.
Inventor(s):	Gold; Elijah H. (West Orange, NJ), Neustadt; Bernard R. (West Orange, NJ), Smith; Elizabeth M. (Verona, NJ)
Assignee:	Schering Corporation (Kenilworth, NJ)
Filing Date:	Sep 28, 1988
Application Number:	07/250,300
Claims:	1. A process for the preparation of cis,endo-octahydrocyclopenta[b]pyrrole-2-carboxylates which comprises: (1) the reaction of a halo pyruvate ester with benzyliminocyclopentane in an inert solvent in the presence of a base at 0.degree.-100.degree. C. for about 2-8 hours; and (2) catalytically reducing the product of step 1 to form cis,endo-octahydrocyclopenta[b]-pyrrole-2-carboxylate.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. We do not provide individual investment advice. This service is not registered with any financial regulatory agency. The information we publish is educational only and based on our opinions plus our models. By using DrugPatentWatch you acknowledge that we do not provide personalized recommendations or advice. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.