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Details for Patent: 4,831,157

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Details for Patent: 4,831,157

Title: Preparation of angiotensin-converting enzyme inhibitors
Abstract:Novel compounds with angiotensin-converting enzyme inhibitory activity are disclosed. Such compounds are useful in the treatment of cardiovascular disorders, especially hypertension and congestive heart failure, and are useful in the treatment of glaucoma. Also disclosed is a novel process for preparing intermediates useful in the preparation of the claimed compounds.
Inventor(s): Gold; Elijah H. (West Orange, NJ), Neustadt; Bernard R. (West Orange, NJ), Smith; Elizabeth M. (Verona, NJ)
Assignee: Schering Corporation (Kenilworth, NJ)
Filing Date:Sep 28, 1988
Application Number:07/250,300
Claims:1. A process for the preparation of cis,endo-octahydrocyclopenta[b]pyrrole-2-carboxylates which comprises:

(1) the reaction of a halo pyruvate ester with benzyliminocyclopentane in an inert solvent in the presence of a base at 0.degree.-100.degree. C. for about 2-8 hours; and

(2) catalytically reducing the product of step 1 to form cis,endo-octahydrocyclopenta[b]-pyrrole-2-carboxylate.
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