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|Abstract:||This application discloses certain substituted phenylacetonitriles of the formula: ##STR1## in which the dotted line represents optional unsaturation, and R.sub.4 is hydrogen or alkyl; R.sub.5 and R.sub.6, one of which may be hydrogen, are ortho or para substituents, independently selected from the group consisting of hydroxyl, alkyl, alkoxy, aralkoxy, alkanoyloxy, alkylmercapto, halo or trifluoromethyl; R.sub.7 is hydrogen or alkyl; and n is one of the integers 0, 1, 2, 3 or 4; which are useful in the production of antidepressant agents.|
|Inventor(s):||Husbands; G. E. Morris (Berwyn, PA), Yardley; John P. (Gulph Mills, PA), Muth; Eric A. (West Chester, PA)|
|Assignee:||American Home Products Corporation (New York, NY)|
|Filing Date:||May 22, 1985|
|Claims:||1. A compound of the formula: ##STR16## in which the dotted line represents optional unsaturation, and R.sub.4 is hydrogen or alkyl of 1 to 6 carbon atoms; |
R.sub.5 and R.sub.6, one of which may be hydrogen, are ortho or para substituents, independently selected from the group consisting of hydroxyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, aralkoxy of 7 to 9 carbon atoms, alkanoyloxy of 2 to 7 carbon atoms, alkylmercapto of 1 to 6 carbon atoms, halo or trifluoromethyl;
R.sub.7 is hydrogen or alkyl of 1 to 6 carbon atoms; and
n is one of the integers 0, 1, 2, 3 or 4.
2. The compound of claim 1 which is 1-[cyano(p-methoxyphenyl)methyl]cyclohexanol.
3. The compound of claim 1 which is 1-[cyano(p-chlorophenyl)methyl]cyclohexanol.
4. The compound of claim 1 which is 1-[cyano(3-bromo-4-methoxyphenyl)methyl]cyclohexanol.
5. The compound of claim 1 which is 1-[2-cyano-2-(4-methoxyphenyl)ethyl]cyclohexanol.
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