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Details for Patent: 3,978,124

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Details for Patent: 3,978,124

Title: 6-Substituted 2-naphthyl .alpha.-substituted acetamides
Abstract:2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturated at positions 3 and 4, are anti-inflammatory, analgesic, anti-pyretic and anti-pruritic agents. A pharmaceutical method of effecting treatment of inflammation, pain, pyrexia and pruritus by the administration of naphthyl acetic acid derivatives. A pharmaceutical composition for use in the treatment of the above maladies comprising a naphthyl acetic acid derivative.
Inventor(s): Fried; John H. (Palo Alto, CA), Harrison; Ian J. (Palo Alto, CA)
Assignee: Syntex Corporation (Panama, PM)
Filing Date:Mar 17, 1975
Application Number:05/558,583
Claims:1. 6-Trifluoromethyl-2-naphthyl-.alpha.-methylacetamide.

2. 6-Fluoro-2-naphthyl-.alpha.-methylacetamide.

3. 6-Chloro-2-naphthyl-.alpha.-methylacetamide.

4. 6-Methoxy-2-naphthyl-.alpha.-methylacetamide.

5. 6-Difluoromethoxy-2-naphthyl-.alpha.-methylacetamide.

6. 6-Methoxymethyloxy-2-naphthyl-.alpha.-methylacetamide.

7. 6-Methylthio-2-naphthyl-.alpha.-methylacetamide.

8. 6-Difluoromethylthio-2-naphthyl-.alpha.-methylacetamide.

9. 6-Methoxy-2-naphthyl-.alpha.-difluoromethylacetamide.
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