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Generated: May 21, 2018

DrugPatentWatch Database Preview

Details for Patent: 3,905,984

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Title: Pyridyl substituted thioalkyl-and oxyalkyl-thioureas and ureas
Abstract:The compounds are pyridyl substituted thioalkyl-and oxyalkyl-thioureas and ureas which are inhibitors of histamine activity.
Inventor(s): Durant; Graham John (Welwyn Garden City, EN), Emmett; John Colin (Codicote, EN), Ganellin; Charon Robin (Welwyn Garden City, EN)
Assignee: Smith Kline & French Laboratories Limited (Welwyn Garden City, EN)
Filing Date:Mar 13, 1974
Application Number:05/450,937
Claims:1. A compound of the formula: ##EQU11## wherein A is such that there is formed together with the carbon atoms shown a pyridine ring; X.sub.1 is hydrogen, lower alkyl, hydroxyl, trifluoromethyl, halogen, amino or ##EQU12## X.sub.2 is hydrogen or, when X.sub.1 is methyl, methyl or halogen, k is 1 or 2 and m is 2 or 3, provided that the sum of k and m is 3 or 4; Y is oxygen or sulphur; E is oxygen or sulphur; R.sub.1 is hydrogen, lower alkyl, benzoyl or di-lower alkylamino-lower alkyl or a pharmaceutically acceptable addition salt thereof; with the proviso that X.sub.1 is ##EQU13## only when Y and E are sulphur and R.sub.1 is methyl and X.sub.1 is nonadjacent to the other alkylthioalkylthiourea group.

2. A compound of claim 1 wherein k is 1 and m is 2.

3. A compound of claim 1 in which X.sub.1 is hydrogen, methyl, bromo, hydroxyl or amino and X.sub.2 is hydrogen; Y and E are sulphur and R.sub.1 is methyl.

4. A compound of claim 1, said compound being N-methyl-N'-[2-((3-hydroxy-2-pyridyl)methylthio)ethyl]thiourea.

5. A compound of claim 1, said compound being M-methyl-N'-[2-((3-bromo-2-pyridyl)methylthio)ethyl]thiourea.

6. A compound of claim 1, said compound being N-methyl-N'-[2-(2-pyridylmethylthio)ethyl]thiourea.

7. A compound of claim 1, said compound being N-methyl-N'-[2-((3-methyl-2-pyridyl)methylthio)ethyl]thiourea.

8. A compound of claim 1, said compound being N-methyl-N'-[2-((6-methyl-2-pyridyl)methylthio)ethyl]thiourea.

9. A compound of claim 1, said compound being N-methyl-N'-[2-(3-pyridylmethylthio)ethyl]thiourea.

10. A compound of claim 1, said compound being N-methyl-N'-[2-(4-pyridylmethylthio)ethyl]thiourea.

11. A compound of claim 1, said compound being N-methyl-N'-[2-(2-pyridylmethylthio)ethyl]urea.

12. A compound of claim 1, said compound being N-methyl-N'-[2-((3-amino-2-pyridyl)methylthio)ethyl]-thiourea.

13. A compound of claim 1, said compound being N-methyl-N'-[2-((5-hydroxy-2-pyridyl)methylthio)ethyl]thiourea.

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