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Generated: August 21, 2017

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Title:Crystal modification of a N-phenyl-2-pyrimidineamine derivative, processes for its manufacture and its use
Abstract: The invention relates to a new crystalline form of the methanesulfonic acid addition salt of 4-(4-methylpiperazin-1-yl-methyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin- -2-ylamino)phenyl]-benzamide of formula I, which may be used for example for tumour therapy. ##STR00001##
Inventor(s): Zimmermann; Juerg (Basel, CH), Sutter; Bertrand (Hesingue, FR), Buerger; Hans Michael (Allschwil, CH)
Assignee: Novartis AG (Basel, CH)
Application Number:13/238,967
Patent Claims: 1. A crystalline form of the monomethanesulfonic acid addition salt of a compound of formula I, ##STR00004## having non-needle-shaped crystals.

2. A crystalline form according to claim 1 of the methanesulfonic acid addition salt of a compound of formula I, which comprises at least 95% by weight crystals of the .beta.-modification.

3. A crystalline form according to claim 1 of the methanesulfonic acid addition salt of a compound of formula I, which shows on X-ray diffraction a peak at an angle of refraction 2theta of 20.degree., said peak having a relative line intensity of about 65% as compared to the most intense line in the diagram.

4. A pharmaceutical composition, comprising the crystal form according to claim 1 of the methanesulfonic acid addition salt of a compound of formula I and a pharmaceutically acceptable carrier.
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Moodys
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Chubb

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