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Summary for Patent: RE43932
|Title:||Crystal modification of a N-phenyl-2-pyrimidineamine derivative, processes for its manufacture and its use|
|Abstract:||The invention relates to a new crystalline form of the methanesulfonic acid addition salt of 4-(4-methylpiperazin-1-yl-methyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin- -2-ylamino)phenyl]-benzamide of formula I, which may be used for example for tumour therapy. ##STR00001##|
|Inventor(s):||Zimmermann; Juerg (Basel, CH), Sutter; Bertrand (Hesingue, FR), Buerger; Hans Michael (Allschwil, CH)|
|Assignee:||Novartis AG (Basel, CH)|
|Patent Litigation and PTAB cases:||See patent lawsuits and PTAB cases for patent RE43932|
1. A crystalline form of the monomethanesulfonic acid addition salt of a compound of formula I, ##STR00004## having non-needle-shaped crystals.
2. A crystalline form according to claim 1 of the methanesulfonic acid addition salt of a compound of formula I, which comprises at least 95% by weight crystals of the .beta.-modification.
3. A crystalline form according to claim 1 of the methanesulfonic acid addition salt of a compound of formula I, which shows on X-ray diffraction a peak at an angle of refraction 2theta of 20.degree., said peak having a relative line intensity of about 65% as compared to the most intense line in the diagram.
4. A pharmaceutical composition, comprising the crystal form according to claim 1 of the methanesulfonic acid addition salt of a compound of formula I and a pharmaceutically acceptable carrier.
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