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Serving 500+ biopharmaceutical companies globally:

US Department of Justice
Express Scripts
Chinese Patent Office
Farmers Insurance
Dow
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Fuji
Daiichi Sankyo
Cantor Fitzgerald
Colorcon

Generated: June 23, 2017

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Claims for Patent: RE39050

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Claims for Patent: RE39050

Title:Methods of use for inhibiting bone loss and lowering serum cholesterol
Abstract:A method of inhibiting bone loss or resorption, or lowering serum cholesterol, comprising administering to a human in need thereof a compound having the formula ##STR00001## or a pharmaceutically acceptable salt or solvate thereof, in a low dosage amount. Also encompassed by the invention is a a pharmaceutical formulation in unit dosage form comprising, per unit dosage, a low dosage amount.
Inventor(s): Draper; Michael W. (Carmel, IN), Black; Larry J. (Franklin, IN)
Assignee: Eli Lilly and Company (Indianapolis, IN)
Application Number:10/375,274
Patent Claims: 1. A method of inhibiting .Iadd.post-menopausal .Iaddend.bone loss .[.or bone resorption.]. .Iadd.in a post-menopausal woman in need of treatment to prevent or to treat post-menopausal osteoporosis .Iaddend.comprising administering to .[.a human.]. .Iadd.said woman .Iaddend.in need .[.thereof.]. .Iadd.of said treatment .Iaddend.a compound of formula I ##STR00003## or a pharmaceutically acceptable salt or solvate thereof, in an amount of .[.about 50 to about 150 .]. .Iadd.55 to 65 .Iaddend.mg/day.

2. A method of claim 1 wherein .[.the human.]. .Iadd.said woman .Iaddend.has been diagnosed as suffering from .Iadd.post-menopausal.Iaddend.osteoporosis.

.[.3. A method of claim 1 wherein the human is a post-menopausal female..].

.[.4. A method of claim 1 wherein the human is a male..].

5. A method of claim 1 wherein the compound is administered prophylactically.

.[.6. A method of claim 1 wherein the compound of formula I is administered in an amount of about 60 to about 150 mg/day..].

7. A method of claim 1 wherein the compound of formula I is administered in an amount of 60 mg/day.

8. A method of claim 1 wherein the compound of formula I is administered in an amount of .[.75.]. .Iadd.55 .Iaddend.mg/day.

9. A method of claim 1 wherein the compound of formula I is administered in an amount of .[.100.]. .Iadd.65 .Iaddend.mg/day.

.[.10. A method of claim 1 wherein the compound of formula I is administered in an amount of 125 mg/day..].

.[.11. A method of claim 1 wherein the compound of formula I is administered in an amount of 150 mg/day..].

12. A method of claim 1 .[.wherein the compound is the.]. .Iadd.which comprises administering a .Iaddend.hydrochloride salt .Iadd.of a compound of formula I.Iaddend..

.Iadd.13. A method of claim 12 wherein the hydrochloride salt is administered in an amount of 60 mg/day..Iaddend.

.Iadd.14. A method of preventing post-menopausal osteoporosis in a post-menopausal woman in need of treatment to prevent post-menopausal osteoporosis comprising administering to said woman a hydrochloride salt of a compound of Formula I ##STR00004## in an amount of 60 mg/day..Iaddend.

.Iadd.15. A method of treating post-menopausal osteoporosis in a post-menopausal woman in need of treatment for post-menopausal osteoporosis comprising administering to said woman a hydrochloride salt of a compound of Formula I ##STR00005## in an amount of 60 mg/day..Iaddend.
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Serving 500+ biopharmaceutical companies globally:

Julphar
Harvard Business School
McKesson
Healthtrust
Novartis
UBS
US Army
Covington
Teva
Accenture

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