Claims for Patent: RE39050

Summary for Patent: RE39050

Title:	Methods of use for inhibiting bone loss and lowering serum cholesterol
Abstract:	A method of inhibiting bone loss or resorption, or lowering serum cholesterol, comprising administering to a human in need thereof a compound having the formula or a pharmaceutically acceptable salt or solvate thereof, in a low dosage amount. Also encompassed by the invention is a a pharmaceutical formulation in unit dosage form comprising, per unit dosage, a low dosage amount.
Inventor(s):	Michael W. Draper, Larry J. Black
Assignee:	Eli Lilly and Co
Application Number:	US10/375,274
Patent Claims:	1. A method of inhibiting post-menopausal bone loss or bone resorption in a post-menopausal woman in need of treatment to prevent or to treat post-menopausal osteoporosis comprising administering to a human said woman in need thereof of said treatment a compound of formula I or a pharmaceutically acceptable salt or solvate thereof, in an amount of about 50 to about 150 55 to 65 mg/day. 2. A method of claim 1 wherein the human said woman has been diagnosed as suffering from post-menopausalosteoporosis. 3. A method of claim 1 wherein the human is a post-menopausal female. 4. A method of claim 1 wherein the human is a male. 5. A method of claim 1 wherein the compound is administered prophylactically. 6. A method of claim 1 wherein the compound of formula I is administered in an amount of about 60 to about 150 mg/day. 7. A method of claim 1 wherein the compound of formula I is administered in an amount of 60 mg/day. 8. A method of claim 1 wherein the compound of formula I is administered in an amount of 75 55 mg/day. 9. A method of claim 1 wherein the compound of formula I is administered in an amount of 100 65 mg/day. 10. A method of claim 1 wherein the compound of formula I is administered in an amount of 125 mg/day. 11. A method of claim 1 wherein the compound of formula I is administered in an amount of 150 mg/day. 12. A method of claim 1 wherein the compound is the which comprises administering a hydrochloride salt of a compound of formula I. 13. A method of claim 12 wherein the hydrochloride salt is administered in an amount of 60 mg/day. 14. A method of preventing post-menopausal osteoporosis in a post-menopausal woman in need of treatment to prevent post-menopausal osteoporosis comprising administering to said woman a hydrochloride salt of a compound of Formula I in an amount of 60 mg/day. 15. A method of treating post-menopausal osteoporosis in a post-menopausal woman in need of treatment for post-menopausal osteoporosis comprising administering to said woman a hydrochloride salt of a compound of Formula I in an amount of 60 mg/day.