|Title:||Anticonvulsant enantiomeric amino acid derivatives|
|Abstract:||The present invention is directed to a compound in the R configuration about the asymmetric carbon in the following formula: ##STR1## pharmaceutical compositions containing same and the use thereof in treating CNS disorders in animals.|
|Inventor(s):||Kohn; Harold (Chapel Hill, NC)|
|Assignee:||Research Corporation Technologies, Inc. (Tucson, AZ)|
1. A compound in the R configuration having the formula: ##STR11##
wherein Ar is phenyl which is unsubstituted or substituted with at least one halo group; Q is lower alkoxy, and Q.sub.1 is methyl.
2. The compound according to claim 1 which is substantially enantiopure.
3. The compound according to claim 1 wherein Q is lower alkoxy containing 1-3 carbon atoms.
4. The compound according to claim 3 wherein Q is methoxy.
5. The compound according to claim 1 wherein Ar is unsubstituted phenyl.
6. The compound according to claim 1 wherein halo is fluoro.
7. The compound according to claim 1 wherein Q is alkoxy containing 1-3 carbon atoms and Ar is unsubstituted phenyl.
8. The compound according to claim 1 which is (R)-N-Benzyl 2-Acetamido-3-methoxypropionamide.
9. The compound according to claim 8 which contains at least 90% (w/w) R stereoisomer.
10. A therapeutic composition comprising an anticonvulsant effective amount of a compound according to any one of claims 1-9 and a pharmaceutical carrier therefor.
11. A method of treating central nervous system disorders in an animal comprising administering to said animal in need thereof an anticonvulsant effective amount of a compound according to any one of claims 1-9.
12. The method according to claim 11 wherein the animal is a mammal.
13. The method according to claim 12 wherein the mammal is a human.
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