.

Deeper Knowledge, Faster

  • Identify first generic entrants
  • Obtain formulation and manufacturing information
  • Set up watchlists for daily email updates

► See Plans & Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving 500+ biopharmaceutical companies globally:

McKinsey
Mallinckrodt
Colorcon
Deloitte
McKesson
US Department of Justice
Dow
AstraZeneca
Citi
Johnson and Johnson

Generated: June 25, 2017

DrugPatentWatch Database Preview

Claims for Patent: RE34878

« Back to Dashboard

Claims for Patent: RE34878

Title: Hypoglycemic agent
Abstract:A compound of D-phenylalanine derivative for hypoglycemic use, represented by the general formula ##STR1## R.sup.1 is selected from hydrogen, alkyl of 1 to 5 carbon atoms, aryl of 6 to 12 carbon atoms, aralkyl of 6 to 12 carbon atoms, ##STR2## --CH.sub.2 CO.sub.2 R.sup.3, --CH(CH.sub.3)--OCO--R.sup.3, and --CH.sub.2 --OCO--C(CH.sub.3).sub.3 ; R.sup.2 is selected from groups comprising aryl of 6 to 12 carbon atoms, a hetero six-membered ring, a hetero five-membered ring, cycloalkyl, or cycloalkenyl, any of which groups may have one or more substituents; and R.sup.3 is selected from hydrogen and alkyl of 1 to 5 carbon atoms; the salts thereof, and precursors which can be converted thereto in the human or animal body. Some of the compounds are novel per se.
Inventor(s): Toyoshima; Shigeshi (Funabashi, JP), Seto; Yoshiko (Funabashi, JP), Shinkai; Hisashi (Kawasaka, JP), Toi; Koji (Kanagawa, JP), Kamashiro; Izumi (Yokohama, JP)
Assignee: Ajinomoto Co., Inc. (Tokyo, JP)
Application Number:08/157,564
Patent Claims: 1. A D-phenylalanine derivative of the formula

or a salt thereof or a precursor which can be converted into said D-phenylalanine derivative in vivo, wherein:

R.sup.1 is hydrogen or C.sub.1-5 alkyl,

R.sup. is hydrogen or C.sub.1-5 alkyl; and

R.sup.4 is cyclohexane substituted at the 4- or 5-position by methyl, ethyl, ispropyl, tert-butyl, ethene, or isopropene or cyclohexene substituted at the 4- or 5-position by methyl, ethyl, isopropyl, tert-butyl, ethene, or isopropene.

2. The D-phenylalanine derivative of claim 1, wherein R.sup.4 is said substituted cyclohexane.

3. The D-phenylalanine derivative of claim 1, wherein R.sup.4 is said substituted cyclohexane.

4. The D-phenylalanine derivative of claim 1, wherein the said derivative is N-(4-isopropylcyclohexylcarbonyl)-D-phenylalanine.

5. The D-phenylalanine derivative of claim 1, wherein the said derivative is N-(4-isopropylcyclohexylcarbonyl)-D-phenylalanine: N-[(S)-perilloyl]-D-phenylalanine; N-(4-methylcyclohexylcarbonyl)-D-phenylalanine; N-(4-ethylcyclohexylcarbonyl)-D-phenylalanine; or N-(4-t-butylcyclohexylcarbonyl)-D-phenylalanine.

6. The D-phenylalanine derivative of claim 1, wherein the said derivative is N-[(s)-perilloyl]-D-phenylalanine; N-(trans-4-methylcyclohexylcarbonyl)-D-phenylalanine; N-(trans-4-ethylcyclohexylcarbonyl)-D-phenylalanine; N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine; or N-(trans-4-t-butylcyclohexylcarbonyl)-D-phenylalanine.

7. The D-phenylalanine derivative of claim 1, wherein R.sup.1 is hydrogen and R.sup.3 is hydrogen.

8. The D-phenylalanine derivative of claim 1, wherein R.sup.4 is perilloyl.

9. The D-phenylalanine derivative of claim 1, wherein said substituted cyclohexane is substituted at the 4-position.

10. The D-phenylalanine derivative of claim 1, wherein said substituted cyclohexane is substituted at the 5-position.

11. The D-phenylalanine derivative of claim 1, wherein said substituted cyclohexene is substituted at the 4-position.

12. The D-phenylalanine derivative of claim 1, wherein said substituted cyclohexene is substituted at the 5-position.

13. The D-phenylalanine derivative of claim 1, wherein said substituted cyclohexane or said substituted cyclohexene is substituted with methyl, ethyl, isopropyl or tert-butyl.

14. The D-phenylalanine derivative of claim 1, wherein said substituted cyclohexane or said substituted cyclohexene is substituted by ethene, or isopropene.

15. A pharmaceutical composition, comprising a D-phenylalanine derivative of claim 1 and a pharmaceutical excipient. .Iadd.16. The compound N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine. .Iaddend.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Serving 500+ biopharmaceutical companies globally:

Boehringer Ingelheim
Merck
Fuji
Express Scripts
US Department of Justice
Covington
Deloitte
Chubb
Medtronic
Federal Trade Commission

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2017 thinkBiotech LLC
ISSN: 2162-2639

Secure SSL Encrypted

Follow DrugPatentWatch:



Google
Twitter
Google Plus
botpot