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|Title:||Ether of n-propanol amine|
|Abstract:||.[.Ethers.]. .Iadd.An ether .Iaddend.of n-propanolamine, preparation thereof and .[.their.]. .Iadd.its .Iaddend.use in treatment of cardiovascular conditions.|
|Inventor(s):||Busch; Norbert (Loubeyrat, FR), Simond; Jacques (Chamalieres, FR), Monteil; Andre (Gerzat, FR), Moleyre; Jacques (Mozac, FR), Mauvernay; Roland Y. (Riom, FR)|
|Assignee:||Centre Europeen de Recherches Mauvernay (Riom, FR)|
1. An ether of n-propanolamine having the formula.]. ##STR33## .[.wherein A is morpholino, pyrrolidino, piperidyl, and di-lower-alkyl amino, R is a straight or branched chain lower
alkyl, or benzyl, Ar is aryl and Ar.sup.1 is aryl or pyridyl, and pharmacologically acceptable |
salts thereof..]. .[.2. The ether of claim 1 in which A is pyrrolidino, R is isobutyl and Ar and Ar.sup.1 are both phenyl, and the hydrochloride thereof..]. .[.3. The ether of claim 1 in which A is pyrrolidino, R is isobutyl, Ar is phenyl and Ar.sup.1 is 2-pyridyl, and the acid fumarate thereof..]. .[.4. The ether of claim 1 in which A is diethylamino, R is an isobutyl and Ar and Ar.sup.1 are both phenyl, and the acid fumarate thereof..]. .[.5. The ether of claim 1 in which A is morpholino, R is isobutyl and Ar and Ar.sup.1 are both phenyl and the acid fumarate thereof..]. .[.6. The ether of claim 1 in which A is piperidyl, R is benzyl and Ar and Ar.sup.1 are both phenyl and the hydrochloride thereof..]..Iadd. 7. An ether having the formula .Iaddend. ##STR34## .Iadd.and pharmaceutically acceptable acid addition salts thereof.
.Iaddend. .Iadd. 8. An ether according to claim 7 wherein the acid addition salt is the hydrochloride or the acid fumarate. .Iaddend.
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