Claims for Patent: 9,956,188

Summary for Patent: 9,956,188

Title:	Eutectic formulations of cyclobenzaprine hydrochloride and amitriptyline hydrochloride
Abstract:	The present invention relates to pharmaceutical compositions and methods of manufacturing the same, comprising a eutectic of Cyclobenzaprine HCl and mannitol or Amitriptyline HCl and mannitol.
Inventor(s):	Marino Nebuloni, Patrizia Colombo
Assignee:	Tonix Pharma Holdings Ltd , Redox SRL
Application Number:	US15/459,093
Patent Claims:	1. A eutectic of mannitol and cyclobenzaprine HCl, comprising 75%±2% cyclobenzaprine HCl and 25%±2% mannitol by weight. 2. The eutectic of claim 1, wherein the cyclobenzaprine HCl is micronized cyclobenzaprine HCl. 3. A method of manufacturing the eutectic of claim 1, said method comprising mixing cyclobenzaprine HCl and mannitol or milling cyclobenzaprine HCl and mannitol, wherein the eutectic comprises 75%±2% cyclobenzaprine HCl and 25%±2% mannitol by weight. 4. The method of claim 3, comprising milling cyclobenzaprine HCl and mannitol. 5. The method of claim 4, wherein, the cyclobenzaprine HCl and mannitol are milled in a high shear granulator. 6. The method of claim 3, comprising mixing cyclobenzaprine HCl and mannitol. 7. The method of claim 6, wherein the cyclobenzaprine HCl and mannitol are mixed via compression. 8. The method of claim 7, wherein the cyclobenzaprine HCl and mannitol are compressed via roller compaction. 9. The method of claim 3, wherein the cyclobenzaprine HCl is micronized cyclobenzaprine HCl.