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Last Updated: March 30, 2023

Claims for Patent: 9,890,141

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Summary for Patent: 9,890,141
Title:Crystalline pharmaceutical and methods of preparation and use thereof
Abstract: Novel crystalline polymorphic forms, Forms A, B, C, D, and E of a compound of Formula I, which has been found to be a potent inhibitor of LFA-1, are disclosed. Methods of preparation and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed in this invention. ##STR00001##
Inventor(s): Burnier; John (Pacifica, CA)
Assignee: SARCODE BIOSCIENCE INC. (Brisbane, CA)
Application Number:15/144,892
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 9,890,141
Patent Claims: 1. A composition comprising an isolated compound of Formula I: ##STR00020## wherein said compound is synthesized according to a method comprising the steps: performing hydrolysis of Formula AA with a base: ##STR00021## wherein R is a carbon containing moiety; and isolating the compound of Formula I, wherein the hydrolysis is performed in a solution comprising acetone, the composition is essentially free of a chemical catalyst, and the compound of Formula I is isolated by way of recrystallization from a solution comprising acetone.

2. The composition of claim 1, wherein R is a substituted or unsubstituted group selected from lower alkyl, lower alkenyl, lower alkynyl, cyclo(lower)alkyl, cyclo(lower)alkenyl, aryl, aralkyl, heterocyclyl, and heteroaryl groups.

3. The composition of claim 1, wherein R is benzyl.

4. The composition of claim 1, wherein the base is sodium hydroxide.

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