Claims for Patent: 9,877,955

Summary for Patent: 9,877,955

Title:	Compositions and methods for treating diseases of the nail
Abstract:	Methods and compositions for treating disorders of the nail and nail bed. Such compositions contain a vehicle in which all components of the composition are dissolved, suspended, dispersed, or emulsified, a non-volatile solvent, a wetting agent, and a pharmaceutically active ingredient that is soluble in the non-volatile solvent and/or a mixture of the vehicle and the non-volatile solvent, and which composition is effective in treating a disorder of the nail or nail bed.
Inventor(s):	Winckle; Gareth (Biot, FR), Fieldson; Gregory T. (Morgantown, WV)
Assignee:	Dow Pharmaceutical Sciences, Inc. (Petaluma, CA)
Application Number:	15/332,909
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 9,877,955
Patent Claims:	1. A method for the treatment of onychomycosis comprising topically applying to the surface of the nail of an individual suffering from onychomycosis a pharmaceutical composition comprising: 50% w/w to 70% w/w ethanol, 8% w/w to 15% w/w diisopropyl adipate, 8% w/w to 15% w/w C12-15 alkyl lactate, 10% w/w to 15% w/w cyclomethicone, and 2% w/w to 15% w/w (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidine-1-yl)-1-(1H-1,2,4- -triazole-1-yl)butane-2-ol; wherein the composition is formulated as a solution; and wherein the application of the composition is in an amount and for a time sufficient to ameliorate the symptoms of the onychomycosis. 2. The method of claim 1, wherein the pharmaceutical composition comprises about 12% w/w diisopropyl adipate, about 10% w/w C12-15 alkyl lactate, and about 13% w/w cyclomethicone. 3. The method of claim 2, wherein the pharmaceutical composition comprises about 10% w/w (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidine-1-yl)-1-(1H-1,2,4- -triazole-1-yl)butane-2-ol. 4. The method of claim 1, wherein the pharmaceutical composition comprises about 57% w/w ethanol. 5. The method of claim 4, wherein the pharmaceutical composition comprises about 10% w/w (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidine-1-yl)-1-(1H-1,2,4- -triazole-1-yl)butane-2-ol. 6. The method of claim 1, wherein the pharmaceutical composition does not comprise a polymeric film forming compound. 7. The method of claim 2, wherein the pharmaceutical composition does not comprise a polymeric film forming compound. 8. The method of claim 3, wherein the pharmaceutical composition does not comprise a polymeric film forming compound. 9. The method of claim 4, wherein the pharmaceutical composition does not comprise a polymeric film forming compound. 10. The method of claim 5, wherein the pharmaceutical composition does not comprise a polymeric film forming compound. 11. The method of claim 1, wherein the pharmaceutical composition is administered twice daily to the surface of the nail. 12. The method of claim 1, wherein the pharmaceutical composition is administered once daily to the surface of the nail. 13. The method of claim 1, wherein the pharmaceutical composition is administered one weekly to the surface of the nail. 14. A method for the treatment of onychomycosis comprising topically applying to the surface of the nail of an individual suffering from onychomycosis a pharmaceutical composition comprising: 50% w/w to 70% w/w ethanol, about 12% w/w diisopropyl adipate, about 10% w/w C12-15 alkyl lactate, about 13% w/w cyclomethicone, and about 10% w/w (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidine-1-yl)-1-(1H-1,2,4- -triazole-1-yl)butane-2-ol; wherein the composition is formulated as a solution; and wherein the application of the composition is in an amount and for a time sufficient to ameliorate the symptoms of the onychomycosis.