Claims for Patent: 9,802,954

Summary for Patent: 9,802,954

Title:	Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma
Abstract:	Piperidino-dihydrothienopyrimidine sulfoxides of formula I wherein:
Inventor(s):	Pascale A. J. Pouzet, Peter Nickolaus, Ulrike Werthmann, Rogelio P. Frutos, Bing-Shiou Yang, Soojin Kim, Jason Alan Mulder, Nitinchandra D. Patel, Chris Hugh Senanayake, Thomas Gabriel Tampone, Xudong Wei
Assignee:	Boehringer Ingelheim International GmbH
Application Number:	US13/963,513
Patent Claims:	1. A method of treating COPD, asthma or idiopathic pulmonary fibrosis comprising the step of administering to a patient in need thereof an effective amount of a compound of formula I wherein: Ring A is a 6-membered aromatic ring optionally comprising one or two nitrogen atoms, R is Cl and is located in the para-, meta-, or ortho-position of Ring A, and S* is a sulphur atom that represents a chiral center, or of a pharmaceutically acceptable salt thereof. 2. The method of claim 1, wherein R is Cl and is located in the para-position of Ring A. 3. The method of claim 1, wherein Ring A is phenyl, pyridinyl, or pyrimidinyl. 4. The method of claim 1, wherein the compound of formula I is 5. The method of claim 1, wherein the compound of formula I is 6. The method of claim 1, wherein S* is in the R-configuration. 7. The method of claim 2, wherein S* is in the R-configuration. 8. The method of claim 4, wherein S* is in the R-configuration. 9. The method of claim 5, wherein S* is in the R-configuration. 10. The method of claim 1, wherein S* is in the S-configuration. 11. The method of claim 2, wherein S* is in the S-configuration. 12. The method of claim 4, wherein S* is in the S-configuration. 13. The method of claim 5, wherein S* is in the S-configuration. 14. The method of claim 5, wherein the compound of formula I shows a reflex peak in the X-ray powder diffraction diagram with a d-value of 4.62 Å. 15. The method of claim 5, wherein the compound of formula I shows reflex peaks in the X-ray powder diffraction diagram with d-values of 4.62 Å, 6.82 Å, and 10.09 Å. 16. The method of claim 5, wherein the compound of formula I shows reflex peaks in the X-ray powder diffraction diagram with d-values of 4.62 Å, 4.17 Å, and 3.66 Å. 17. The method of claim 5, wherein the compound of formula I shows reflex peaks in the X-ray powder diffraction diagram with d-values of 4.62 Å, 6.82 Å, 10.09 Å, 3.93 Å, and 4.94 Å. 18. The method of claim 5, wherein the compound of formula I shows reflex peaks in the X-ray powder diffraction diagram with d-values of 4.62 Å, 4.17 Å, 3.66 Å, 3.73 Å, and 18.47 Å. 19. The method of claim 5, wherein the compound of formula I shows a reflex peak in the X-ray powder diffraction diagram with a d-value of 4.12 Å. 20. The method of claim 5, wherein the compound of formula I shows reflex peaks in the X-ray powder diffraction diagram with d-values of 4.12 Å, 4.29 Å, and 5.15 Å. 21. The method of claim 5, wherein the compound of formula I shows reflex peaks in the X-ray powder diffraction diagram with d-values of 4.12 Å, 4.29 Å, 5.15 Å, 3.95 Å, and 3.36 Å.