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Last Updated: March 28, 2024

Claims for Patent: 9,724,353


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Summary for Patent: 9,724,353
Title:Methods for treating intrapulmonary infections
Abstract: This disclosure relates to the treatment of intrapulmonary bacterial infections, including treatment of nosocomial pneumonia lung infections with pharmaceutical compositions containing the cephalosporin ceftolozane.
Inventor(s): Chandorkar; Gurudatt A. (Waltham, MA), Huntington; Jennifer A. (Reading, MA), Parsons; Tara (Hanover, MA), Umeh; Obiamiwe C. (Acton, MA)
Assignee: MERCK SHARP & DOHME CORP. (Rahway, NJ)
Application Number:14/512,608
Patent Claims: 1. A method of treating an infection selected from the group consisting of: nosocomial pneumonia, ventilator acquired pneumonia and hospital acquired pneumonia, the method comprising repeatedly intravenously administering 2.0 g of ceftolozane and 1.0 g of tazobactam to a subject in need thereof about once every 8 hours.

2. The method of claim 1, wherein the method comprises administering the ceftolozane as a 60-minute infusion.

3. The method of claim 1, wherein the ceftolozane is a hydrogen sulfate salt.

4. The method of claim 1, wherein the ceftolozane and tazobactam are administered as a single pharmaceutical composition.

5. The method of claim 4, wherein the method comprises administering the pharmaceutical composition as a 60-minute infusion.

6. The method of claim 1, wherein the pneumonia is nosocomial pneumonia.

7. The method of claim 1, wherein the pneumonia is ventilator acquired pneumonia.

8. The method of claim 1, wherein the pneumonia is hospital acquired pneumonia.

9. The method of claim 1, wherein the ceftolozane is administered in its free base form.

10. The method of claim 1, wherein the ceftolozane is administered in its salt form.

11. The method of claim 6, wherein the ceftolozane is administered in its free base form.

12. The method of claim 6, wherein the ceftolozane is administered in its salt form.

13. The method of claim 1, wherein the infection comprises one or more pathogens selected from the group consisting of: Pseudomonas aeruginosa, E. coli and K. pneumoniae.

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