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Last Updated: December 16, 2025

Claims for Patent: 9,687,571

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Summary for Patent: 9,687,571

Title:	Stabilization of radiopharmaceutical compositions using ascorbic acid
Abstract:	Radiopharmaceutical compositions, and related methods, useful for medical imaging are provided. The radiopharmaceutical compositions include one or more radiopharmaceutical compounds, together with a stabilizer comprising ascorbic acid, wherein the pH of said composition is within the range of about 3.5-5.5.
Inventor(s):	James F. Castner, Dianne D. Zdankiewicz, James E. Anderson
Assignee:	Bristol Myers Squibb Pharma Co, Lantheus Medical Imaging Inc, ACP Lantern Acquisition Inc
Application Number:	US13/264,276
Patent Claims:	1. A composition, comprising a radiopharmaceutical compound of formula: and ascorbic acid, wherein the pH of said composition is within a range of about 3.5 to less than 6; and wherein the composition comprises between about 25 mg/mL and 500 mg/mL of ascorbic acid. 2. The composition of claim 1 wherein the composition comprises greater than about 50 mg/mL of ascorbic acid. 3. A method for preparing a radiopharmaceutical composition of claim 1, comprising: contacting a first solution comprising a radiopharmaceutical compound of formula: with a second solution comprising ascorbic acid within a pH range of about 3.5 to less than 6, to form the radiopharmaceutical composition comprising the radiopharmaceutical compound and ascorbic acid, wherein the composition comprises between about 25 mg/mL and 500 mg/mL of ascorbic acid. 4. A method of myocardial imaging a patient, comprising: administering to the patient a radiopharmaceutical composition comprising a radiopharmaceutical compound of formula: and ascorbic acid, wherein the pH of the composition is within a range of about 3.5 to less than 6, and wherein the composition comprises between about 25 mg/mL and 500 mg/mL of ascorbic acid; and obtaining a myocardial image of the patient. 5. The composition of claim 1, wherein the composition comprises between about 25 mg/mL and 200 mg/mL of ascorbic acid. 6. The composition of claim 1, wherein the composition comprises greater than about 40 mg/mL of ascorbic acid. 7. The composition of claim 1, wherein the composition comprises between about 50 mg/mL and 200 mg/mL of ascorbic acid. 8. The composition of claim 1, wherein the composition comprises about 50 mg/mL of ascorbic acid. 9. The composition of claim 1, wherein said pH is within the range of about 5.5 to less than 6. 10. The composition of claim 9, wherein the pH is 5.8. 11. The composition of claim 5, wherein said pH is within the range of about 5.5 to less than 6. 12. The composition of claim 11, wherein the pH is 5.8.

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