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Last Updated: April 19, 2024

Claims for Patent: 9,687,443

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Summary for Patent: 9,687,443

Title:	Compositions containing alpha-2-adrenergic agonist components
Abstract:	Compositions useful for improving effectiveness of alpha-2-adrenergic agonist components include carrier components, alpha-2-adrenergic agonist components, solubility enhancing components which aid in solubilizing the alpha-2-adrenergic agonist components. In one embodiment, the alpha-2-adrenergic agonist components include alpha-2-adrenergic agonists. In another embodiment, the solubility enhancing components include carboxymethylcellulose.
Inventor(s):	Graham; Richard (Irvine, CA), Bakhit; Peter (Huntington Beach, CA), Olejnik; Orest (Coto De Caza, CA)
Assignee:	ALLERGAN, INC. (Irvine, CA)
Application Number:	15/048,607
Patent Claims:	1. A therapeutically effective aqueous ophthalmic composition comprising: a solution containing 0.1% (w/v) of a compound selected from the group consisting of brimonidine, a salt of brimonidine, and an ester of brimonidine, wherein the solution further comprises an oxy-chloro preservative and carboxymethylcellulose, wherein the composition has a pH between 7.0-8.0. 2. The composition of claim 1 which comprises about 0.1% (w/v) of brimonidine tartrate. 3. The composition of claim 1 which comprises 0.1% (w/v) of brimonidine tartrate. 4. The composition of either of claim 3 wherein the carboxymethyl cellulose enhances the solubility of brimonidine tartrate in solution. 5. The composition of claim 3 further comprising boric acid. 6. The composition of claim 3 further comprising sodium borate. 7. The composition of claim 3 further comprising hydrochloric acid. 8. The composition of claim 7 wherein the composition has a ph of 7.4-8.0. 9. The composition of claim 1, wherein the composition comprises 0.1% w/v brimonidine tartrate, 0.5% w/v carboxymethyl cellulose, 0.005% w/v oxy-chloro preservative, 0.6% w/v boric acid, 0.045% w/v sodium borate decahydrate, 0.37% w/v sodium chloride, 0.14% w/v potassium chloride, 0.006% w/v calcium chloride dihydrate, 0.006% w/v magnesium chloride hexahydrate, and water.

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