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Last Updated: April 24, 2024

Claims for Patent: 9,549,926

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Summary for Patent: 9,549,926

Title:	Compositions and methods of treating pulmonary hypertension
Abstract:	Provided are formulations comprising therapeutically effective amounts of ambrisentan or a pharmaceutically acceptable salt thereof and tadalafil or a pharmaceutically acceptable salt thereof and methods of treating and/or preventing pulmonary hypertension by administration of the formulations.
Inventor(s):	Belardinelli; Luiz (Palo Alto, CA), Gillies; Hunter Campbell (El Granada, CA), Liang; Faquan (San Francisco, CA), Shryock; John (East Palo Alto, CA), Yang; Suya (Palo Alto, CA)
Assignee:	Gilead Sciences, Inc. (Foster City, CA)
Application Number:	14/079,548
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 9,549,926
Patent Claims:	1. A method for treating pulmonary arterial hypertension in a human patient in need thereof, comprising co-administering to the patient a therapeutic amount of ambrisentan and a therapeutically effective amount of tadalafil, wherein the weight ratio of the ambrisentan to the tadalafil is about 1:2 or about 1:3. 2. The method of claim 1, wherein the weight ratio of the ambrisentan to the tadalafil is about 1:2. 3. The method of claim 1, wherein the ambrisentan and the tadalafil are administered in a sequential manner. 4. The method of claim 1, wherein the ambrisentan and the tadalafil are administered at the same time. 5. The method of claim 1, wherein the ambrisentan and the tadalafil are administered orally or parenterally. 6. The method of claim 1, wherein the weight ratio of the ambrisentan to the tadalafil is about 1:3.

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